ID G3WXZ2_SARHA Unreviewed; 1285 AA.
AC G3WXZ2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN Name=SMC4 {ECO:0000313|Ensembl:ENSSHAP00000020297.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000020297.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000020297.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000020297.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC4 subfamily.
CC {ECO:0000256|ARBA:ARBA00006005}.
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DR STRING; 9305.ENSSHAP00000020297; -.
DR Ensembl; ENSSHAT00000020458.2; ENSSHAP00000020297.2; ENSSHAG00000017214.2.
DR eggNOG; KOG0996; Eukaryota.
DR GeneTree; ENSGT00900000141094; -.
DR InParanoid; G3WXZ2; -.
DR TreeFam; TF101158; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:Ensembl.
DR GO; GO:0000794; C:condensed nuclear chromosome; IEA:Ensembl.
DR GO; GO:0000796; C:condensin complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0051383; P:kinetochore organization; IEA:Ensembl.
DR GO; GO:0010032; P:meiotic chromosome condensation; IEA:Ensembl.
DR GO; GO:0045132; P:meiotic chromosome segregation; IEA:Ensembl.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:Ensembl.
DR GO; GO:1905821; P:positive regulation of chromosome condensation; IEA:Ensembl.
DR GO; GO:0051984; P:positive regulation of chromosome segregation; IEA:Ensembl.
DR GO; GO:1905820; P:positive regulation of chromosome separation; IEA:Ensembl.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR18937:SF172; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 610..725
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 324..586
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 766..828
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 896..1007
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 21..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1285 AA; 146146 MW; 06AEA22474874196 CRC64;
MPPRKRTKPS TAQQPSAAAE PDVPEPEPPP PADAADAAKP PDPEPPGPEP DLRSLEEILG
AVPPPPPPAM TNEAGAPRLM ITHIVNLNFK SYAGRKLLGP FHKRFSCIIG PNGSGKSNVI
DSMLFVFGYR AQKIRSKKLS VLIHNSDEHR DLDSCSVEVH FQKIVDKEED DYEVIPDSGF
SVSRTAYRDN SSVYHISGKK ATFRDVGHLL RSHGIDLDHN RFLILQGEVE QIAMMKPKGQ
TEHDEGMLEY LEDIIGCGRL KEPIQVLCRR VEILNEQRGE KLNRVKMVEK EKDALEGEKN
AAIEFLTLEN EVFKKKNHVC QYYIHDLQKR IAEMETQKEK IHEDTKDINK KSSKLADEMK
AKTKALKDVE KKLNKVTKFI EENKEKFTQL DLEDVQVREK MKHAKNKAKK LEKQLQKDKE
KVEEFKGVPA SSEKIITETT ARKTILEKEK EKEEEKLKQV MDSLKQETKE LQKEKESQEK
ELMEFSKTVN EARSKMDVAQ SELDIYLSHH NTAVSQLSEA KKALTTASET LKERKAAIRD
LEIKLPPTEQ DLKEKENELQ KLTKEATDIE NSVRDLIQKV EEAKSSFATN HSRGKVLSAL
IQQKKSGKIP GIYGRLGDLG AIDEKYDIAI SSCCGALDYI VVDTIDTAQV CVNFLKKQNI
GVATFIGLDK IKVLEKNMNP IQTPENTPRL FDLVKVKDEN IRRAFYFALH DTLVANNLDQ
ATRVAFQKDK RWRVVTLQGQ IIEQSGTMTG GGTKLMKGRM GSSLVVEVSE EEVAQMESKL
QKDSQKAVQI QERKAQLEEM VMKLRHRVQD MRNTLEKFTA SIQSLSEQEA YLGVQVKELE
ANVRDTAPDK KKQKLLETNI SIFKKEYECV AAKAGKVEAE VKRLHNLIVE INNHKLKAQQ
DKLDKINHQL DECASAITKA QVAVKTADRN LKKAQDSVLR TEKEIKDNEK EVEDLGHELK
NLEEKATEVM KNSKEAGESL PEIQKEHHNL LQEMKAIKEN EHALQNDALS IKLKLEQLDS
HIAEHHSKVK YWQKEISRIS LHPIEDKPVE EISPLSPEDL EAIQSPDSLT NQIALLEAQC
HEMKPNLGSI AEYKKKEELY LQRVAELDKI TAERERFRQA YEDLRKQRLN EFMAGFNIIT
NKLKENYQML TLGGDAELEL VDSLDPFSEG IMFSVRPPKK SWKKIFNLSG GEKTLSSLAL
VFALHHYKPT PLYFMDEIDA ALDFKNVSIV AFYIYEQTKN AQFIIISLRN NMFEIADRLI
GIYKTHNITK SVAINPKVIA SKGLC
//
