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Database: UniProt
Entry: G3WZY4_SARHA
LinkDB: G3WZY4_SARHA
Original site: G3WZY4_SARHA 
ID   G3WZY4_SARHA            Unreviewed;       469 AA.
AC   G3WZY4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   31-JAN-2018, entry version 45.
DE   RecName: Full=Triacylglycerol lipase {ECO:0000256|RuleBase:RU362046};
DE            EC=3.1.1.3 {ECO:0000256|RuleBase:RU362046};
DE   AltName: Full=Pancreatic lipase {ECO:0000256|RuleBase:RU362046};
GN   Name=PNLIPRP2 {ECO:0000313|Ensembl:ENSSHAP00000020989};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000020989, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000020989}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000020989}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a
CC       carboxylate. {ECO:0000256|RuleBase:RU362046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00591292}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000020989}.
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DR   EMBL; AEFK01004718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01004719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003755397.1; XM_003755349.1.
DR   STRING; 9305.ENSSHAP00000020989; -.
DR   Ensembl; ENSSHAT00000021159; ENSSHAP00000020989; ENSSHAG00000017796.
DR   GeneID; 100920499; -.
DR   KEGG; shr:100920499; -.
DR   CTD; 5408; -.
DR   eggNOG; ENOG410IHRX; Eukaryota.
DR   eggNOG; ENOG410Y92X; LUCA.
DR   GeneTree; ENSGT00760000119069; -.
DR   InParanoid; G3WZY4; -.
DR   KO; K14075; -.
DR   OMA; PWDPKDI; -.
DR   OrthoDB; EOG091G0DJ5; -.
DR   TreeFam; TF324997; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 2.60.60.20; -; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002331; Lipase_panc.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00823; PANCLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR000865-3,
KW   ECO:0000256|RuleBase:RU362046, ECO:0000256|SAAS:SAAS00709807};
KW   Lipid degradation {ECO:0000256|RuleBase:RU362046};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU362046};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Secreted {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|RuleBase:RU362046}.
FT   SIGNAL        1     17       {ECO:0000256|RuleBase:RU362046}.
FT   CHAIN        18    469       Triacylglycerol lipase.
FT                                {ECO:0000256|RuleBase:RU362046}.
FT                                /FTId=PRO_5005132063.
FT   DOMAIN      357    469       PLAT. {ECO:0000259|PROSITE:PS50095}.
FT   ACT_SITE    171    171       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    195    195       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    282    282       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   DISULFID     21     27       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    109    120       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    256    280       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    304    315       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    318    323       {ECO:0000256|PIRSR:PIRSR000865-3}.
FT   DISULFID    453    469       {ECO:0000256|PIRSR:PIRSR000865-3}.
SQ   SEQUENCE   469 AA;  52940 MW;  44AA44FCF1319775 CRC64;
     MFQFWTITLF FLATVRGKEI CFKRLGCFSN DKPWSGTLQR PFKVLPWSPE EIDIRFLLYT
     NENPNNFQTI LPDDPSTIEG SNFKMDRKTR FIIHGFIDKG EESWLKDMCQ QMFQVEKVNC
     FCIDWKRGAR TRYAQAINNI RVVGAELAYL INVLKTEFGY SLSDVHIIGH SLGAHAAGEA
     GRRLQGQIGR ITGLDPAEPC FQNAPEEVRL DASDAMFVDV IHTDSAPMLP NLGFGMSQTV
     GHLDFFPNGG KQMPGCQKNI LSTIIDINGI WEGTRDFVAC NHLRSYKYYS SSILQPDGFL
     GYPCSSYEVF NSDACFPCPA EGCPRMGHYA DQFKGKTNAL GQTFFLNTGE KANFTRWRYR
     VSVTLSGGKK LSGYIRIAMY GNNGVSKQYD IFKGSLRPGA RHKKEIDVDI NVGKVEQVKF
     LWYNNVINLF RPKLGASKVT VQTGEDGTEY HFCSNDTVRE DVLQTLSSC
//
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