ID G3X104_SARHA Unreviewed; 1171 AA.
AC G3X104;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000021359.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000021359.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000021359.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR AlphaFoldDB; G3X104; -.
DR STRING; 9305.ENSSHAP00000021359; -.
DR Ensembl; ENSSHAT00000021532.2; ENSSHAP00000021359.2; ENSSHAG00000018102.2.
DR eggNOG; KOG0791; Eukaryota.
DR GeneTree; ENSGT00940000156870; -.
DR HOGENOM; CLU_001541_2_0_1; -.
DR TreeFam; TF351926; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd14615; R-PTPc-J; 1.
DR CDD; cd12087; TM_EGFR-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF5; PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 812..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 202..289
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 375..464
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 465..555
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 875..1132
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1050..1123
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1171 AA; 130582 MW; 88C750A95A566105 CRC64;
EVTLTWKNLH QAASQYKYIV QYQQAREAKV ITSWHPNITV TDLAAGTYYA FSISGWFPDP
RVFQPNPVSD LQVTDVGLAD ATLSWHSDNG TVAARLLFKA FEDETNSFSQ MILNISHLEP
GFQYQFPPFL PDPCQAQGDS NATQSRPGEH GIGFPISQNT LTRVHVTGLN SGTSYQATVF
SQAANGTEGD PLMRIFETNS SQVVNVRIAE VSDTGVKLFW ENTDNSSSYT YRIQVAGDGH
SFDQNSNDTH VAITGLNSST LYNFTVYPKR NYDPEGQPVF TQTYTAPHPV SDFRVQNFNT
TSISLAWSSE GSSFRILVKD LTHHLFSRNE TQQEKQLVVT DLIPGTLYCF EIFPQAPDGR
EGVSRKLEQT TEPNAVSSIE VVFVNTTTIH LQWQNRDSVS LGYRYLLLVE TSGSWVFNST
TSFLNETIGG LEPGTCYNVT IYPEVGNGTK GSPVWKIVYT TPSPVSAISV SSISTTEVTL
SWEETDSAAA GYTYLILLVE GGSGMFINQT LRVRNATITG LSPGTSYNVT IYSQVGEDLL
QGEPGHTSFC TDAASVAFLE CNPVPKQPIL ILRWPCPPGV NSGFSLTIHS GEWSKEINLP
PCYSTYVNDD YNGTYVASLN YSTTYNISLI TLSCGKKSFP KQNISRTSIT DPPPPDGLPN
IFPINHNSLK VKFGKFESSH GPITAYAVIL TTDGSANKSS ADFLKYTYED FKKGTSKTYV
TYLMTVKEER AASALSDVLK YEVIVGNEST TDGYYNGKLE PLSSYRACIA GFTNITFDSL
HPGLINGTES YVSFSFYSDA VSLPQNPAVI CGAVFGCIFG ALVIVAVGGF IFWRRKRKDA
KNSDVSFSQI KSKIIKVENF ESYFKKQQAD SNCGFAEEYE DLKLIGVNQP KFAAEIPENR
GKNRYNNVLP YDISRVKLSI QTQVTDDYIN ANYMPGYYSK KDFIATQGPL PNTLKDFWRM
VWEKNIYSIV MLTKCVEQGR TKCEEYWPSK QTQNYGDITV AMTSEIILPE WTIRDFTVKN
SKTSESHPLR QFHFTSWPDH GVPDTTDLLI NFRYLVNDYM KQSPPESPVL VHCSAGVGRT
GTFIAIDRLI HQMENENAVD VYGIVYDLRL HRPLMVQTED QYVFLNQCVW DIIKSQKDSK
ADLIYQNTTA MTIYENLAPM TAFGKTNGYI A
//
