ID G3X2F3_SARHA Unreviewed; 801 AA.
AC G3X2F3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Leucine rich repeat containing 8 VRAC subunit B {ECO:0000313|Ensembl:ENSSHAP00000021858.1};
GN Name=LRRC8B {ECO:0000313|Ensembl:ENSSHAP00000021858.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000021858.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000021858.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000021858.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR AlphaFoldDB; G3X2F3; -.
DR STRING; 9305.ENSSHAP00000021858; -.
DR Ensembl; ENSSHAT00000022033.2; ENSSHAP00000021858.1; ENSSHAG00000018504.2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160703; -.
DR HOGENOM; CLU_019019_0_0_1; -.
DR OMA; CYERELH; -.
DR TreeFam; TF331443; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF36; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT B; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..331
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 801 AA; 92346 MW; C07678715C004399 CRC64;
MLSLSELKYI ADSQSSCHIL KPWWDVFWYY LTLIMLLVAV LSGALQLADT KILCCLPCKV
ELNDRCVVPL DMFKLNSTPS NSVSQVTPPI RIQNDLHKQQ YAYIDAVCYE KQLHWFAKFF
PYLVLLHTLI FAACSNFWLH YPSTSSRIEH FVSILHKCFD SPWTTRALSE TVAEQSVSVP
LRKSRVLFSP SGLSTNTSAS KQSLHIGQSN METGLESPTS SVLDKKEGEQ AKAIFEKVKR
FRLHVEQKDV IYRVYMKQII IKVILFLIII AYVPYFLTYI TLEIDCPIDM QAFTGYKRYH
CVYALAEIFQ VLASFYVIMV LFYGLTSSYS LWWMLRSSLK EYSFEALREK SNYSDIPDVK
NDFAFILHLA DQYDPLYSKR FSIFLSEVSE NKLKQINLNN EWTMEKLKNK LVKNCQDKVE
LHLFMLSGLP DNVFELTEIE VLTLELIPEV KLPPAISTLI NLRELNLYHS SLLVDRPALN
FLEDNLKILR LKFTERGKIP RWIFHLKNLK ELYLSGYIIS DTLSTLSAVQ SPAPGFQDLR
NLRTLYLKST LSRIPQVITD TLPALQKLSL DNEGNKLVVL NNLKKMVNLK SLELINCDLE
RIPHSIFSLI HLHELNLKEN NLKTIEEIIS FQHLQNLSSL KLWHNHIAYI PAQIGALSNL
EQLYLDHNKI ENMPLQLFLC TKLTHLDLSY NNLTFIPEEI QFLTNLLYFA VTSNYIETLP
NGLFQCKKLQ TLLLGRNSLM TLPPLIGELT NLIQLELVGN HLEVLPPELE ACPSLKRSCV
LVEENLLNTL SPPPTERWHS G
//
