ID G3X6G8_BOVIN Unreviewed; 941 AA.
AC G3X6G8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Leucine rich repeat containing G protein-coupled receptor 6 {ECO:0000313|Ensembl:ENSBTAP00000006288.6};
GN Name=LGR6 {ECO:0000313|Ensembl:ENSBTAP00000006288.6};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000006288.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000006288.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006288.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000006288.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006288.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; G3X6G8; -.
DR STRING; 9913.ENSBTAP00000006288; -.
DR PaxDb; 9913-ENSBTAP00000006288; -.
DR Ensembl; ENSBTAT00000006288.6; ENSBTAP00000006288.6; ENSBTAG00000004789.6.
DR VEuPathDB; HostDB:ENSBTAG00000004789; -.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG2087; Eukaryota.
DR GeneTree; ENSGT00940000159939; -.
DR HOGENOM; CLU_006843_0_0_1; -.
DR InParanoid; G3X6G8; -.
DR OMA; YGVCAGF; -.
DR OrthoDB; 4257264at2759; -.
DR TreeFam; TF316814; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000004789; Expressed in saliva-secreting gland and 63 other cell types or tissues.
DR ExpressionAtlas; G3X6G8; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
DR GO; GO:1990523; P:bone regeneration; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR002131; Gphrmn_rcpt_fam.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF77; GPR INSULIN LIKE RECEPTOR 1; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01462; LRRNT; 1.
DR PRINTS; PR00373; GLYCHORMONER.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..941
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018629563"
FT TRANSMEM 560..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 682..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 804..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..67
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT REGION 873..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 100498 MW; 8FCD790A1E2C4795 CRC64;
MPRAPRLLPL WLCAAALCAP PAAPPPRPRP GCPVPCRCRE AGILLWVDCS ERGLSTVPAG
LDPLTAYLDL SMNSLTELWP GVFHHLRFLE ELRLSGNRLA HIPGQAFSGL SSLKILMLQN
NRLGGIPAEA LWELPGLQSL RLDANLISLV PDRSFEGLTS LRHLWLDDNA LTEIPVRALS
HLRALQAVTL ALNRIGRVPD YAFWNLSSLV VLHLHNNRIR HLGAHSFEGL QNLETLDLNC
NQLHEFPVAI QTLGRLQELG FHNNNIRAIP EKAFLGNPLL QTIHFYDNPI QFVGRSAFQH
LPGLHTLSLN GATDIQEFPD LRGTTSLESL TLTRAGLQRL PPGMCQQLPR LRVLELSHNR
IEGLPSLRGC QKLEEIGLQH NRIWEVRADT FRELTFLRSL DLSWNAIRSI HPEAFSTLRS
LVKLDLTGNQ LSVLPLAGLG GLVHLKLRGN RALSQAFPKD SFPRLRTLEV PYAYQCCAYS
GCPGFFTASG LRGPQHPPPD AQDPPKRTLA DRAESRYDLD PEELQLEMEE PRPQPAVQCS
PAPGPFQPCE HLFESWGVRL AVWAVVLLAL LCNALVLLSL SVAGPGPLPP AKFVVGALAG
ANALTGLSCG LLASVDALTF GQFAEFGARW EAGPGCRAAG FLAVLGSEAS VLLLSLGAAH
CSVAAACVRA RGKAPAAGSV RAGALGCLAL AGLLAALPLA SVGEYGASPL CLPHAPPAGR
PAALGFAVAL VLLHAACLLA AALACIRLSC RLPAAGLEAS WDCAAVRHVA WLTFADGLLY
CPVAFLSLAS ALGLLPVTPE AVKAVLLLVL PLPACLNPLL YLLFSPHSRE DLRRLRPCWG
GPREPSSCDS TQALVAFPDV ELTAEASETQ GLPLGALVPR QQPGGLKLEG GHVAEPEGTR
FGQQPPSRDG GRAQGTPEAS LAGRGRAGGG GFQSSGLASG V
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