ID G3X809_BOVIN Unreviewed; 491 AA.
AC G3X809;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Cytochrome P450 family 46 subfamily A member 1 {ECO:0000313|Ensembl:ENSBTAP00000046805.4};
GN Name=CYP46A1 {ECO:0000313|Ensembl:ENSBTAP00000046805.4,
GN ECO:0000313|VGNC:VGNC:110269};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000046805.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000046805.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046805.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000046805.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000046805.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
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DR AlphaFoldDB; G3X809; -.
DR Ensembl; ENSBTAT00000050034.4; ENSBTAP00000046805.4; ENSBTAG00000035544.4.
DR VEuPathDB; HostDB:ENSBTAG00000035544; -.
DR VGNC; VGNC:110269; CYP46A1.
DR eggNOG; KOG0157; Eukaryota.
DR GeneTree; ENSGT00940000156927; -.
DR HOGENOM; CLU_001570_5_1_1; -.
DR TreeFam; TF352037; -.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000035544; Expressed in floor plate of diencephalon and 51 other cell types or tissues.
DR ExpressionAtlas; G3X809; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0033781; F:cholesterol 24-hydroxylase activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0006707; P:cholesterol catabolic process; IEA:InterPro.
DR CDD; cd20613; CYP46A1-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR039983; CYP46A1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24293:SF1; CHOLESTEROL 24-HYDROXYLASE; 1.
DR PANTHER; PTHR24293; CYTOCHROME P450 FAMILY 46 SUBFAMILY A; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..491
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018553810"
SQ SEQUENCE 491 AA; 55546 MW; 08B160A092793ADE CRC64;
MSPGLLMLLG SAVLVVFGLC CTFVHRARSR YEHIPGPPRP SFLLGHLPYF WKKDEVCGRV
LQDVFLDWAK KYGPVVRVNV FHKTSVIVTS PESVKKFLMS TKYNKDSKMY HAIQTVFGER
LFGQGLVSEC DYERWHKQRR IMDLAFSRSS LVGLMGTFNE KAEQLVEILE AQADGQTPVS
MQDMLTCATM DILAKAAFGM ETSMLLGAQK PLSRKVKLIL EGISASRNTL AKFMPGKWKQ
LRETRESVRF LRQVGKEWVQ RRREALQRGE DVPADILTQI LKAEEGAQDD EILLDNFVTF
FIAGHETSAN HLAFTVMELS RQPEILARLQ AEVDEVIGSK RHLDCEDLGR LQYLSQVLKE
SLRLYPPAWG TFRLLEEETL IDGVRVPGNT PLLVRGALPS PLLLQGPRGW GPRQPWRLAP
SSTPLTHPPR PLRAQMEVKV VMAKLLQRLE FRLVPGQRFG LQEQATLKPL DPVLCTLQPR
GWQPAPPPPP C
//
