ID   G3XAQ0_MYCTH            Unreviewed;       279 AA.
AC   G3XAQ0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=probable enoyl-COA hydratase {ECO:0000313|PDB:3T3W};
GN   ORFNames=NODE_3842_LENGTH_7261_COV_7.913097_27 {ECO:0000313|PDB:3T3W};
OS   Mycolicibacterium thermoresistibile (Mycobacterium thermoresistibile).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1797 {ECO:0000313|PDB:3T3W};
RN   [1] {ECO:0007829|PDB:3T3W}
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH ZINC.
RX   PubMed=25613812; DOI=10.1016/j.tube.2014.12.003;
RA   Baugh L., Phan I., Begley D.W., Clifton M.C., Armour B., Dranow D.M.,
RA   Taylor B.M., Muruthi M.M., Abendroth J., Fairman J.W., Fox D.,
RA   Dieterich S.H., Staker B.L., Gardberg A.S., Choi R., Hewitt S.N.,
RA   Napuli A.J., Myers J., Barrett L.K., Zhang Y., Ferrell M., Mundt E.,
RA   Thompkins K., Tran N., Lyons-Abbott S., Abramov A., Sekar A.,
RA   Serbzhinskiy D., Lorimer D., Buchko G.W., Stacy R., Stewart L.J.,
RA   Edwards T.E., Van Voorhis W.C., Myler P.J.;
RT   "Increasing the structural coverage of tuberculosis drug targets.";
RL   Tuberculosis 95:142-148(2015).
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|ARBA:ARBA00005254}.
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DR   PDB; 3T3W; X-ray; 1.80 A; A/B/C/D/E/F=20-279.
DR   PDBsum; 3T3W; -.
DR   AlphaFoldDB; G3XAQ0; -.
DR   SMR; G3XAQ0; -.
DR   EvolutionaryTrace; G3XAQ0; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   PANTHER; PTHR43802; ENOYL-COA HYDRATASE; 1.
DR   PANTHER; PTHR43802:SF1; IP11341P-RELATED; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000313|PDB:3T3W, ECO:0007829|PDB:3T3W};
KW   Metal-binding {ECO:0007829|PDB:3T3W}; Zinc {ECO:0007829|PDB:3T3W}.
FT   BINDING         102
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007829|PDB:3T3W"
FT   BINDING         163
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007829|PDB:3T3W"
FT   BINDING         252
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007829|PDB:3T3W"
FT   BINDING         256
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007829|PDB:3T3W"
SQ   SEQUENCE   279 AA;  30932 MW;  2240158C0006EFE2 CRC64;
     GSMVAPSWRR PSRPEQRTEM YIDYDVSDRI ATITLNRPEA ANAQNPELLD ELDAAWTRAA
     EDNDVSVIVL RANGKHFSAG HDLRGGGPVP DKLTLEFIYA HESRRYLEYS LRWRNVPKPS
     IAAVQGRCIS GGLLLCWPCD LIIAAEDALF SDPVVLMDIG GVEYHGHTWE LGPRKAKEIL
     FTGRAMTAEE VAQTGMVNRV VPRDRLDAET RALAGEIAKM PPFALRQAKR AVNQTLDVQG
     FYAAIQSVFD IHQTGHGNAM SVSGWPVLVD IEEMKANIK
//