ID G3XFX2_CALMI Unreviewed; 274 AA.
AC G3XFX2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ornithine carbamoyltransferase {ECO:0000256|ARBA:ARBA00013007};
DE EC=2.1.3.3 {ECO:0000256|ARBA:ARBA00013007};
DE Flags: Fragment;
OS Callorhinchus milii (Ghost shark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
OX NCBI_TaxID=7868 {ECO:0000313|EMBL:BAK96220.1};
RN [1] {ECO:0000313|EMBL:BAK96220.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:BAK96220.1};
RA Takagi W., Kajimura M., Bell J.D., Toop T., Donald J.A., Hyodo S.;
RT "Hepatic and extrahepatic distribution of ornithine urea cycle enzymes in
RT holocephalan elephant fish (Callorhinchus milii).";
RL Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 161:331-340(2012).
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine
CC and carbamoyl phosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004695}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC superfamily. OTCase family. {ECO:0000256|ARBA:ARBA00007805}.
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DR EMBL; AB622984; BAK96220.1; -; mRNA.
DR AlphaFoldDB; G3XFX2; -.
DR UniPathway; UPA00158; UER00271.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:UniProt.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR InterPro; IPR002292; Orn/put_carbamltrans.
DR NCBIfam; TIGR00658; orni_carb_tr; 1.
DR PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45753:SF3; ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL; 1.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00102; OTCASE.
DR SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 2: Evidence at transcript level;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003634};
KW Urea cycle {ECO:0000256|ARBA:ARBA00022436}.
FT DOMAIN 1..141
FT /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02729"
FT DOMAIN 148..273
FT /note="Aspartate/ornithine carbamoyltransferase Asp/Orn-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF00185"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAK96220.1"
FT NON_TER 274
FT /evidence="ECO:0000313|EMBL:BAK96220.1"
SQ SEQUENCE 274 AA; 30512 MW; 8A3C8C8856D2C6EC CRC64;
HLLTLKDFDG EEIKQLLWTA NDLKIRIKQK GEILSLMQGK SMAMIFEKRS TRTRISTETG
FSLLGGHPCF LTTQDIHLGV NESRKDTARV LSGMTDLILA RVYKHSDLEQ LAQDGTIPVI
NGLSELYHPI QILADYLTLQ EHFGSLNGLT VAWIGDGNNI LHSLMMSAAK LGMHLHIATP
KGFEPKSSII TFAESLSKQC GTKLFMTNDP SEAANGANVL VTDTWISMGQ EEEKLERLKA
FQGYQITLKT GKFAAPNWAF LHCLPRKQEE VDDA
//
