ID G3Y8A6_ASPNA Unreviewed; 874 AA.
AC G3Y8A6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=FAD-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=ASPNIDRAFT_129569 {ECO:0000313|EMBL:EHA21015.1};
OS Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 /
OS NCTC 3858a / NRRL 328 / USDA 3528.7).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=380704 {ECO:0000313|EMBL:EHA21015.1, ECO:0000313|Proteomes:UP000009038};
RN [1] {ECO:0000313|EMBL:EHA21015.1, ECO:0000313|Proteomes:UP000009038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
RC NRRL 328 / USDA 3528.7 {ECO:0000313|Proteomes:UP000009038};
RX PubMed=21543515; DOI=10.1101/gr.112169.110;
RA Andersen M.R., Salazar M.P., Schaap P.J., van de Vondervoort P.J.,
RA Culley D., Thykaer J., Frisvad J.C., Nielsen K.F., Albang R., Albermann K.,
RA Berka R.M., Braus G.H., Braus-Stromeyer S.A., Corrochano L.M., Dai Z.,
RA van Dijck P.W., Hofmann G., Lasure L.L., Magnuson J.K., Menke H.,
RA Meijer M., Meijer S.L., Nielsen J.B., Nielsen M.L., van Ooyen A.J.,
RA Pel H.J., Poulsen L., Samson R.A., Stam H., Tsang A., van den Brink J.M.,
RA Atkins A., Aerts A., Shapiro H., Pangilinan J., Salamov A., Lou Y.,
RA Lindquist E., Lucas S., Grimwood J., Grigoriev I.V., Kubicek C.P.,
RA Martinez D., van Peij N.N., Roubos J.A., Nielsen J., Baker S.E.;
RT "Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015
RT versus enzyme-producing CBS 513.88.";
RL Genome Res. 21:885-897(2011).
CC -!- SIMILARITY: Belongs to the PheA/TfdB FAD monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00007801}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA21015.1}.
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DR EMBL; ACJE01000015; EHA21015.1; -; Genomic_DNA.
DR AlphaFoldDB; G3Y8A6; -.
DR STRING; 380704.G3Y8A6; -.
DR HOGENOM; CLU_009665_9_3_1; -.
DR Proteomes; UP000009038; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR Gene3D; 3.40.30.20; -; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR012941; Phe_hydrox_C_dim_dom.
DR InterPro; IPR038220; PHOX_C_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR43004:SF4; FAD_BINDING_3 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43004; TRK SYSTEM POTASSIUM UPTAKE PROTEIN; 1.
DR Pfam; PF13561; adh_short_C2; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR Pfam; PF07976; Phe_hydrox_dim; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 300..668
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
FT DOMAIN 693..850
FT /note="Phenol hydroxylase C-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF07976"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHA21015.1"
FT NON_TER 874
FT /evidence="ECO:0000313|EMBL:EHA21015.1"
SQ SEQUENCE 874 AA; 95765 MW; BF21B21EC20A3A0F CRC64;
QFSLHGRTAL VTGGARGCGL AFARGLAQAG ANVAIFDRIP PEEGFLSIER EYGVRTAYYE
VDVSSPDSLA TGFSAFQADF DNALDICVPC AGINRHQTFL EFNYADHQEL LGVNVLGLFH
TAQLAARQMI ANGTKHGSIV LVASMASHVA VRSQLCSAYC GSKGAVRAMC PAIAKELAEY
GIRVNSISPG YVRTEMTAAF PHLIEEWKSA AMNGRIAEPE DIMGACVFLA SDATILAQKW
GYQLTRQSVR TPSLVTNYYN NTHPEATMNV SSPLQTQGIH TMSPSAINEG FPSPSTIPTT
TVVVVGAGPS GLMLTNNLLR YGTPVILLDD RPTATSTGKA DGLQPKTIET LKQLRLSDEL
LRNGAKVYDI CFWESTPQNP TLNRTSRQTH YPDHLVGASD PYILLAHQGM LEDVLIKDIE
ERGGSVQRNS PFVSVSKTSD GSGELEVIYN DNTTNTQKPI RTKYLVGCDG ARSKVRDFIP
GAQLEGEMSN ASWGVLDGII DTDFPDLWSK VAVRSHTAGS ILWIPRERGM TRLYVELSST
DGERVDRAKA TPEYVMARAR EAMQPFRLEW KFIEWFGNYV VGQRVARRFS DPENQIFIAG
DVCPFHPSFS HQCTDLNNKI QAGANTSMHD SVNLAWKLNL VSRGLAPASL LNTYSEERRK
IANDLIAFDA GHVAAFEKGE TALARNFEEN IRFISGVGAE YDAGVVTKSP QSKVKGGIQP
GTLTRPAKVT RYIDANPVDL QLDIPMMGQF RVVLFVADVV GGKGFLEGFC GADALEGVHS
VAKESYKKCP RGLSDEDKYF PLERYTSVSE VVTYGLVTRS EKREFELGDL PELLQKSRWT
VYLDDVEGEE GCTGEWIGEM EREQVGVMVV RPDG
//
