ID G4A685_AGGAC Unreviewed; 620 AA.
AC G4A685;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=SC1083_0324 {ECO:0000313|EMBL:EGY34850.1};
OS Aggregatibacter actinomycetemcomitans serotype e str. SC1083.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Aggregatibacter.
OX NCBI_TaxID=907488 {ECO:0000313|EMBL:EGY34850.1, ECO:0000313|Proteomes:UP000005508};
RN [1] {ECO:0000313|EMBL:EGY34850.1, ECO:0000313|Proteomes:UP000005508}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC1083 {ECO:0000313|EMBL:EGY34850.1,
RC ECO:0000313|Proteomes:UP000005508};
RA Chen C., Kittichotirat W., Asikainen S., Bumgarner R.;
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGY34850.1}.
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DR EMBL; AEJM01000010; EGY34850.1; -; Genomic_DNA.
DR RefSeq; WP_005555937.1; NZ_AEJM01000010.1.
DR AlphaFoldDB; G4A685; -.
DR SMR; G4A685; -.
DR PATRIC; fig|907488.3.peg.320; -.
DR Proteomes; UP000005508; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 212..330
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 447..581
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 384..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 69693 MW; 54B7A8157D6B8B76 CRC64;
MTIRILSPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAD KIQIDIENGG AGLIRIRDNG
IGIAKEELAL ALARHATSKI ADLADLEAIL SLGFRGEALA SISSVSRLTL TSRTAEQREA
WQVYAQGRDM ETTIQPASHP VGTTVEVANL FFNTPARRKF LRSEKTEFSH IDEVIRRIAL
AKFHINFTLT HNGKVLRQYK SAVTHEQKLK RVAAICGEDF IQNALQIDWK HDDLHLSGWV
ALPQFNRPQN DFNYCYVNGR IVRDKIITHA IRQAYAGYLT ADQHPAFVLF IDLNPNEVDV
NVHPTKHEVR FQQSRLVHDF ITLGISNALA SEQMHLNPPP MENAAEEPAG LWETPTYTKP
NRSAAGQNIF APTAGYSATA YAENKSDGAQ KHRQNPPHFS RENAHREQIT QNVLNAHKTL
WTALKTQPQT EMSVTEVSKP NADFLHALAL INNEALLLQQ EQHFYLLSLA RLQHLKLELN
LTLAPTSQPL LIPIIFRLSD DQWQAWLQQK TFFEQIGFAF TEEATQHKIT LQKVSAHLRR
QNLQQVIIAL LNQSIENLPE FLTALLASSA FTPITVLADA VNLLTETEQL LAKQQQIRLV
DLLVEVDWQP YLTQLTQPPR
//
