ID   G4A751_AGGAC            Unreviewed;       930 AA.
AC   G4A751;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Probable zinc protease {ECO:0000313|EMBL:EGY34255.1};
GN   ORFNames=SC1083_0642 {ECO:0000313|EMBL:EGY34255.1};
OS   Aggregatibacter actinomycetemcomitans serotype e str. SC1083.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Aggregatibacter.
OX   NCBI_TaxID=907488 {ECO:0000313|EMBL:EGY34255.1, ECO:0000313|Proteomes:UP000005508};
RN   [1] {ECO:0000313|EMBL:EGY34255.1, ECO:0000313|Proteomes:UP000005508}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC1083 {ECO:0000313|EMBL:EGY34255.1,
RC   ECO:0000313|Proteomes:UP000005508};
RA   Chen C., Kittichotirat W., Asikainen S., Bumgarner R.;
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGY34255.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AEJM01000016; EGY34255.1; -; Genomic_DNA.
DR   AlphaFoldDB; G4A751; -.
DR   SMR; G4A751; -.
DR   PATRIC; fig|907488.3.peg.632; -.
DR   Proteomes; UP000005508; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   PANTHER; PTHR43690:SF34; ZINC PROTEASE PQQL-LIKE; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 3.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:EGY34255.1};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..930
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003461182"
FT   DOMAIN          55..174
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          213..394
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          688..861
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   930 AA;  107201 MW;  ABC5EFC5332FC1D2 CRC64;
     MRNQKTMKKL TALFVLLCSF RLLMACQTGM DPNALPFDPD IKHGKLTNGL QYYTLNNRDP
     KDRVYIRLVV NAGSMHEDDD QKGIAHLVEH MAFNGSKKYP ENTIINALEK LGMKFARDIN
     AFTDFENTVY TLNLDGNSPQ KLSLAFDVIN EWMNHLTILP KDLDGERGVV QEEWRRRLSP
     MLRLGDKKSA IEMAGSRYVL RDPIGDMNII RHISRDRVAD FYHKWYRPDN MSLIVVGDID
     AHKIAQLISQ QLDKPSSRTQ RPLDKIDFSI PLIHHWRVAS IAEQSTNIPA LELSFFEEDK
     QKETVIGYKQ DLIQQIVTRL VNLRLQKWEE SQNNWLDSAN FYRSHLGKQT LQSVFSLQLI
     DTNYLKNITA LFAFIAEIKQ HGFTADELNG EIARLHNLNE KQQNIRPGSL KIANDLIAIA
     ANHQIMLSTK ERYNLNRRFL NEIKVTDLNA TFNQMLALNA KLLLITQPLP EKKLPFDADY
     IEQRWNQAMH SSQNQWENKK HIIKQPHFEF KDGSLVLEKH WDKGDIDEFR LSNGAKLIYH
     YSNKTPNQVH FRAVTSGGLR SVPNQDYHLL RTAITLVDDT GTGELTQADV NNLFGQSPLV
     LATVIDDDKQ GFTGVAKPQD LSSLLTLFRL KLQSAPVSDN VLQKYHRETQ DYFKQIDAET
     KFMQAISYLR RPNTATVYTQ NQNEQLSFTA AQLSQIYQEK ILGKTDFTYF IIGDISRSEV
     EKLAKRYLAT VEIKTQARAY QPGYIHTPKK AFIMRGLSEP RADVEIYLTA ENQWHPEQKY
     ALEILAEIVQ EKLRLVLREK VSGIYSVNSW FSQDPHTPQI EGKIAFSCAP NRAEELIKLT
     HQILDEIIEN GIDETLLRKK QAEQQQLIKR QFDSLVSVAG MIEDSYWQQG NPQSVYLYQR
     LEQLADKPHL EALARKVLVK AARFEAILRQ
//