ID G4F6T0_9GAMM Unreviewed; 472 AA.
AC G4F6T0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Cardiolipin synthetase {ECO:0000313|EMBL:EHA15678.1};
GN Name=cls {ECO:0000313|EMBL:EHA15678.1};
GN ORFNames=HAL1_10477 {ECO:0000313|EMBL:EHA15678.1};
OS Halomonas sp. HAL1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=550984 {ECO:0000313|EMBL:EHA15678.1, ECO:0000313|Proteomes:UP000005692};
RN [1] {ECO:0000313|EMBL:EHA15678.1, ECO:0000313|Proteomes:UP000005692}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain {ECO:0000313|Proteomes:UP000005692};
RX PubMed=22156396; DOI=10.1128/JB.06359-11;
RA Lin Y., Fan H., Hao X., Johnstone L., Hu Y., Wei G., Alwathnani H.A.,
RA Wang G., Rensing C.;
RT "Draft Genome Sequence of Halomonas sp. Strain HAL1, a Moderately
RT Halophilic Arsenite-Oxidizing Bacterium Isolated from Gold-Mine Soil.";
RL J. Bacteriol. 194:199-200(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA15678.1}.
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DR EMBL; AGIB01000045; EHA15678.1; -; Genomic_DNA.
DR RefSeq; WP_008957994.1; NZ_CP130610.1.
DR AlphaFoldDB; G4F6T0; -.
DR PATRIC; fig|550984.5.peg.2037; -.
DR Proteomes; UP000005692; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR CDD; cd09155; PLDc_PaCLS_like_1; 1.
DR CDD; cd09161; PLDc_PaCLS_like_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR022924; Cardiolipin_synthase.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 210..237
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 385..412
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 472 AA; 53448 MW; 148C3FAC3425D338 CRC64;
MTSWLLGTSI LLIHLLGIVS AIMALMSSRT SQGAVAWIIS LLTFPYVALP AYWFFGRPRF
YGYVSARGQR DTVLRRVLVR YRANVEPFVA PSSNADIQAV EQLAMMPLTY GNHATLLIDG
SATFESLFDG IDRAEQYVLI QFFIVRSDAL GQRLKQHLQR AAQRGVRVYF LYDEVGSRQL
NDGYLNDLIS DGVAVSAFRS SRGFKHRFQL NFRNHRKVTV IDGKEGWIGG FNIGVEYLGE
DPRHGPWRDT HLKLEGPSVL GLQEAFWEDW HWATDEVISL NWMAETSSST DHHVVIVPSG
PADRQDTASL LVQQVIHSAK QRLWVTSPYF VPDQGVQDAL RLAAMRGVDV RVMIPERPDH
LLVFLSAFSF LPDMLRAGVK IYRYLPGFLH QKVMLVDNSA ATVGTVNLDN RSFRLNFEIT
AFIPNQDFAA SVEVMLENDF SQCRRVSIDE INQRSMWMKV VSRAAYLMAP VQ
//
