ID   G4LVD2_SCHMA            Unreviewed;       689 AA.
AC   G4LVD2;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 2.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=HEAT repeat protein {ECO:0000313|WBParaSite:Smp_033760.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_033760.1};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of the
RT   human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN   [2] {ECO:0000313|WBParaSite:Smp_033760.1}
RP   IDENTIFICATION.
RC   STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_033760.1};
RG   WormBaseParasite;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   AlphaFoldDB; G4LVD2; -.
DR   EnsemblMetazoa; Smp_033760.1; Smp_033760.1; Smp_033760.
DR   WBParaSite; Smp_033760.1; Smp_033760.1; Smp_033760.
DR   CTD; 8343222; -.
DR   HOGENOM; CLU_020288_0_0_1; -.
DR   InParanoid; G4LVD2; -.
DR   PhylomeDB; G4LVD2; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF32; IMPORTIN N-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REGION          486..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   689 AA;  76478 MW;  F1E1EB0799E7A638 CRC64;
     MFHSSSIVIQ PMEATNLLST LELLCAPKKL DRERGEDQLN KISLTSDEVK LVSSWIEEKL
     EGLSNWEDVF GGITAAIILL RNVDYESLVD VGIVSKLEDQ AVQCHDNPEF RVRIAAGQLM
     GSLCRHAGLS LFIRYLPTVI QGVITNLERN TEAPVSEAEL SLQELNIAKE HSTNLSSSSL
     SIFHDTAGWK NLETWMKCLQ EMVSNLPSKD FIKVDRTTIL ELTFKAVQHV NRFVRETGYD
     VLSTMISRHL CYTEPEAKEP TYINVATQLA KGLSDNWSQV RMAASRAVRT LFEVDPPPGF
     TRDDIYPILL PAMCLNRYYV AEGVRIYSQD TWCRVTQGEG RKLLGQYLVP AVDYYIQQSD
     ADNHAVREAA CASMAEIVTK LDSKLLLPCV GKLLDALIVC FGDESWPVRD AACVALGSLI
     STFPNETRAS GHDDLMASQF LRNLSDSIPS VRDGAAKSIA AILKSVDDQN LFQHYINHIV
     EKIDGLSKQP KESHGAESSR VSGKGPGASH VTVHSGDAAH DSRHTDQVMY SCGSLAPKLH
     KGRKGGGCHD GLHQRASEPW EEADGAIRLI GQISNMFPNR ATDDLIEQLL KGCEYRNYTH
     YPYFLETACD VIAQLCKHLE KPRFKKYMDT FLEVLAISVE SKLPLAVNAA SECLKSMGNR
     FGPSVLRGRI ESHINAFVSE NLIDLLPPV
//