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Database: UniProt
Entry: G4LXE8_SCHMA
LinkDB: G4LXE8_SCHMA
Original site: G4LXE8_SCHMA 
ID   G4LXE8_SCHMA            Unreviewed;      4998 AA.
AC   G4LXE8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   22-NOV-2017, entry version 49.
DE   SubName: Full=Ryanodine receptor related {ECO:0000313|EMBL:CCD59582.1};
GN   ORFNames=Smp_163570 {ECO:0000313|EMBL:CCD59582.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of
RT   the human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCD59582.1}.
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DR   EMBL; CABG01000039; CCD59582.1; -; Genomic_DNA.
DR   RefSeq; XP_018645937.1; XM_018790926.1.
DR   ProteinModelPortal; G4LXE8; -.
DR   STRING; 6183.Smp_163570__mRNA; -.
DR   EnsemblMetazoa; Smp_163570.1; Smp_163570.1:pep; Smp_163570.
DR   GeneDB; Smp_163570.1:pep; -.
DR   GeneID; 8355682; -.
DR   CTD; 8355682; -.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   InParanoid; G4LXE8; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   PhylomeDB; G4LXE8; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 4.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008854};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:CCD59582.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4387   4406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4546   4564       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4608   4634       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4739   4761       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4799   4819       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4873   4896       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       44     98       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      105    151       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    211       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      217    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      289    347       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      559    772       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      988   1187       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4153   4181       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4184   4216       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4159   4170       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4194   4205       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   4998 AA;  559039 MW;  0D10612FAA969477 CRC64;
     MLQSPPPNMP PCVFVLDQAL SVRALQEMLS IQHQSSDGSG QSGHRTLLYG HAIRLKHRES
     NMYLSCLSTS TSQDKLAFDV GLQQNAETEA CWWTIHPASK QRSVGEKVRI GDDLILVSVS
     SERYLHVYGE VISSNGVIAS FQQTLWTVLP VSSGAIRQKS MNMVLGGDVV RLFHGDESLT
     AACATDSRHA VMYEIGAVST SARSLWRIEH TKTKWSAGFF SWGSEIRLRH VTTGRYLGVL
     PSEANGNGHC DVVTLSAHEA TNAASIFLIR PTKDDKKRSE EHETEGMGEP DLRLGETLAY
     LQHAASGRWL SYEAYETRKR GVGRVEEKKA VLLIEGHMDD LFSLVRAQDE EIRSASAIRR
     CTSVFNNFIH ALNYISSPQN ITLPSQQSQC NLSNGHLLGE VTQCLEDLIE FFAQPHPHEE
     HEIQQSKLTA LRNRQNLFQN EGMIGHVLST IERFTGTFQT RREFSQAVGE DKADQFNELG
     NYLYLLLAAL IRGNRENCAQ FATPTRLDWL FNRLELQQGF AEGVLDALHC VLTDSDEALY
     LITERHIRTL IGLLDKQGRD PRVLQALCSL CLGRQGGAVR LNQELIYETL LPQKDLLLQT
     KLVDQCGSVR PNIFVGYKDG GAMYPKWYFE VIIDSLETVT HQPAKIRVGW ANTEGYNAHP
     CGGPGWGAAG LGDDLFSYAF DGSCLWAGGK PKRATIGTDE ATNEEATSNV PLKRGDIIGC
     LLDLTGPVIQ FNVNGRLVRG YFQDFNISGL FYPCMSMNAK ASARFLLGSN QGRLHHGPPP
     GYSPICYARQ PGQKLRLEPV FTFGQLDKYV FTGPLNSPTP QQYVFVPRTV RTSHIQLPNY
     VEMVRDRLAE NLHEMWSMRK IDQGWRYGER RDDENNLHPC LTTFDKLPPS DKQYNVTLAY
     ETLRTIISLG YNITYEPLPE GTRMRTMKLS NGFTQVNGYK PQPLDLTQIR LSVRIEALVD
     QLAENTHNMW ARDRIALGWT YGFVEDQSQK RSPHLVPYSE VDPIIQQSNK DTAIETVKTL
     IAYGYSLEPI SSDSSDPGRG SSNMDYSGPT RTYRGQATRA VTRGKWYYEA EILTSGFIRI
     GWAKKSAPPD LIIGSSSSSY AFAAHQARKW NRNGSVYGTI CRPGDVIGCM MDLVDKTISF
     SLNGELMMDP LGLEIAFKHI KVDEGYVPAF SLGSGQQVKI NYGNDVQSLK FFTYCGLQEG
     YKPLGVNMCR PLPMWYSRED PSLFVDVDRQ HPSLKVNVSS GTTPTFKVTV KQVDYMSPEE
     TQFLRLSLGT QCKDHFTSNF KTFQFDFYFH RSLNERHAHL DALRRQLEPE PIYTHGVGVG
     DSSNLVMMGQ DMSASTLEVR DRRGKKIRLG NMFKKARSRD PSPEVTSTLG GGGGGSLLSG
     GGSSLTGGKR GGAHATTGSL GPGGGGGQGS AGSGSLLSAT AGGFSTGITG PQVTTTQISQ
     LDQNPPGAIG GQRQVQQAGM PAPGALGDMK STGAANLVDE FSFTVLVLPG QDPGLVHIGW
     VTSYFKLAKT SKPDHISGFL HNVSSQLQFD TTHGQLHGHS NQNPLLGDTS GSEDLGKRMS
     QGLSLTCWVD IASGTLGFDL NGRDSGIRFQ VEPSTRLFAA VFYRPTVKEA IHFEFGRRNR
     YTLPITASML RPPRYTSTVL PHRLRVQALE TTIGNLEALD DHFVAADWLK LDINTVKCRL
     RDLQVERSRA RLKVLGSRPA CRYHSHTLEL YRALCCHDNH NVAHYLTNHV DEYQLLHAMT
     ASDMPGPLRS GFIDLMLVMH ISSHVKLKQV TGKEFIVPIP GADGTGNLPV TSPEKTKEDN
     AMSTALNIAG SNGLLKLSDC PPFPLNKLKL LCLDCLVDSV YKGGSIRDPA GGSYEHLLLP
     LVKTINSLLV MGVLDQKDIH TLLAILDPKS FKASLPLRGD STYESLLEFH LPESVKLEIC
     RLLHNLCDLQ LRNRVEQVVK FASKFVQALQ EDQNFRYMAI KKSNLPSSVA ARRTREFRCP
     ASVQMKSLLQ IHDDELEDVE TNPCSEEVKE MLRSFHKLLC NKLGVMLPEN NENNSANKSD
     SDKSADIGFD ELHLHSPLLT RPSDTLSLAS FGPSYPSDEL QTALAQLQLV PPDMGHPEEG
     SGTPPWILKL LWNMIIRHPL TNDSTIEVNE KNEQTSVTQF CHSGKRSLDG LIVYTIVKWA
     KEGFIESLEL IREMFSALHR QYNATEELKN ALEKTYVISG SSQDEVSRLL RSLGRVRSLL
     GVQLGSNEEI LLKNCLWDLM NNKVFFQHPD LTRCLAVHET VMQLMVQTLT KATFEQPGHG
     SHHQQQQQSQ QQRGSTGPTE MVVQCCRFLC YFCRTSRDNQ KAMFEHLSYM LENSSMLLAR
     PSLRGTCPLD VAYSSLMDNN ELALALREKQ LEKVAIYLSR CGVQSNAELL AKGYPDIGWD
     PVEGERFLDF LRFTVWVNGE TVEENANLVV RLLIRRPECL GPALRGGSKV MKHSAGNTGT
     DGLEIPPGGP DGLHAARGST GQLISDTDCQ PNLAGGDDPD YIDLGAAILT FHSILVNLLG
     YCAPDMETVK SESIRARSIL QSLVSMADLE GVLSLRFILP PPKLEVQVTG MPPGLLPEHK
     ASVVLFLERV YGISDAATFL RLLENGFLPD LRAATLLDST VVPDSDMALA LNRYLCNSVL
     PLLTRHTKYL GEEGTAGGLF EATLQTAYRL SKCRSITNHQ REVVCDFLVA LMQQIKPPMM
     SALLKKMVSD LRTLSKESVV SLRALTEFYQ RCGTYYSSDG WTGGRSGDGE TSASEEERSI
     TAHLFILIFE KLSRQPYEPE LFSYALPCLC SIACALPPDY SISQLNAMGQ QNDSLGQNVG
     QSVFTDQMTL NSLIQRFAEH CHDSWALDLI EQGYTFGAQV DEVRRTHPNL RSFSQLPPQE
     QMRYIHPVTD TLKTMLACGW SVDGDENRYR DAPGDTKHLR RQTITSDNLL NYNPSPKDLR
     GVNVTKEMLN MAERLADNAH NIWARQKMSD LEAIGGGVHQ LLVPYDILTD NERKRYRRLT
     HELIKYLQYN GYRLTVRTGS NSTNTNTNKG NGGTAPTSRF AYGLLNKLLD YVDSAMSSVR
     EPMPSTRYST SRSWLSSSQD MKFFVKVVLP LVERYFETQQ AYFLDPVAGA SIDEKKMAAT
     LFCKLFSLLR IKLNTFGHDV KIAVSCLQGL VQTIDVKAIL KMGTAEDFVR SRILPFFVNA
     ADDLCVVVRN LDASRYSHVK GTIKRGACSI DYIHMVLLPV LKSMFEHLGK NECGEYLLVG
     NVQVTCYRIL NALYKLGTTS SKHANRHRAL IGDCLAALAS AFPVAFLEAN LNSNNPLSIT
     FNNRGGDYSL EARDVLEKLS KTIGDLQSII KQVELLAESG ATGASEAPYL IEVTLPMLCS
     YLPNWWRKGP ECMTNATGPL TTVTADLMNR VLGSVLQLIQ TNIDSPHAPW MTRIATRTQP
     IVANSTADML GQYFLPVSER LLEHALIVER VEEAYRAEKR AGSESVGERE EELSCLVEIL
     VRNLFAFYPL LIKFVDRHRS AWLKKPTYET QRLFSAVARM FLVWIRATKF KREEENFVSA
     HEIDRLSLIV PSGENLTPGI NRSRTHTNGR NESSSLKNVK KAKTGPHTSL TVACIKRLLP
     VGLSQLGGRE QELVLSAKRK LIKVQKQYQK MSIMKKTLLN KEQKTQNWQK LLYKKIDRTI
     AATGRHAELA ISTRSEIVDK IQILSKVMHG LYLVDHPPAV SKGSWKKLVS SQRKRAVMAC
     FRMVPLYAMP THRVMNLFIK GYITEWLDYE ESLASLLQTG SLQTSNSSSS QHTYGQDSSS
     CQPDPLTQLL TALCRSASDQ APDDPLYLAY AKIMSKSCSG EDEEEEEENS NEEGSSFQEQ
     EEQKQQLLSE QNRLAERGAA EMVLLQLAAS KGESTPVAQA SIELGIALLL GGNIGVQGRM
     LDYLMKKKLS GFFTSLAGLT QKCSVLDLDT FERCNKAEGL AVGLSDMEGI TNLYDADFTC
     KIFRFLQLLC EGHNLAFQDY LRTQAGNTVS VNLIISTVDY LLRLQESIMD FYWHYSNKDT
     IDESGKNSFV RAIKIGKQVF RSLTEYIQGP CIGNQLALAH SRLWDAVAGF IYVSAQMQDK
     LSRDPDQLDL LREFLNLQKE LMIMLLSMLE GNVVNGPIAK QMVDTLIESS ANVEMILRFF
     DIFLRMKVIT TSEAFLAFDV NGDGWISHRE FRLALEQQKT YSPEEINYII ACVDNNADGK
     VDFKEFTERF YNPAEDIGFN LALLLTNLSE HVPSDPRLER LIDKARGVLD VFEPHLGRIE
     ITGSNGRIER VYFEIRQQHI DQWEAPQIKE SKRSFLHSVV GESGDKEKLE CFVNFCEDTI
     FEMQHAQSIN GDEADIALNR VAAFNRFLEI THLAFIGHIL SVILHCVRPS QLCATWNTLR
     QMTLPDILLT ILGIIVGLII CVGRFGSHLL HLLWYIIVAL ASDISQKRSL THCNSAVRTM
     VPWSVDRISY SKVATTTTAI QHHSTKPSGN WKNNNNITSP NCLTSPNLKK TSTSSAPPGT
     RIPTSVMNTS SPTSPTVNQK QEDECKTKFN TRNYVISLFA SNFYRFKISA LILAFVINFL
     LLFSKVNQIS PNALGDEDAS GNELGGNDGT DTDEELVEWV TSGDTSSYIG PLIALLAAVH
     SILSFSTLVA YYYLKVPLVI FKREKEICRM LEFEGMWISS QPAEDNLRAH WDKLVLSTSS
     FPQMYWDKFV KKKVRNKYSI QYDYDEITKL LGMDKTSSDT ETGGTSLSKF FGDIDIQYLV
     WKWGVVFTDI SFLYLAVYFA ASAFGNLNYF LYACHLLDVA VSFKTLRTII QSVTHNGKQA
     IMLTSIVIYL YTVVAFNFFR KFYVKDNDGV PDPKCNDMKT CFIFHLHTGL RAGGGIGDEI
     EAPDGDESEN YRILFDLTFF FFVIIILLAI IQGLIIDAFG DLRDQLEQVK EDLESKCFIC
     GIGKEYFDKI PHGFEQHVEK EHNFANYMYF LMHIINKPDT EYTGQETYVW ELYQQRCWDF
     FPIGDCFRKQ YEEELQPK
//
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