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Database: UniProt
Entry: G4LY66_SCHMA
LinkDB: G4LY66_SCHMA
Original site: G4LY66_SCHMA 
ID   G4LY66_SCHMA            Unreviewed;       801 AA.
AC   G4LY66;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   25-OCT-2017, entry version 45.
DE   SubName: Full=Cyclic-nucleotide-gated cation channel,putative {ECO:0000313|EMBL:CCD59851.1};
GN   ORFNames=Smp_155040 {ECO:0000313|EMBL:CCD59851.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of
RT   the human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCD59851.1}.
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DR   EMBL; CABG01000043; CCD59851.1; -; Genomic_DNA.
DR   RefSeq; XP_018646204.1; XM_018790575.1.
DR   ProteinModelPortal; G4LY66; -.
DR   STRING; 6183.Smp_155040__mRNA; -.
DR   EnsemblMetazoa; Smp_155040.1; Smp_155040.1:pep; Smp_155040.
DR   GeneDB; Smp_155040.1:pep; -.
DR   GeneID; 8348155; -.
DR   KEGG; smm:Smp_155040; -.
DR   CTD; 8348155; -.
DR   eggNOG; KOG0499; Eukaryota.
DR   eggNOG; ENOG410ZJ5U; LUCA.
DR   InParanoid; G4LY66; -.
DR   KO; K04952; -.
DR   OrthoDB; EOG091G03EW; -.
DR   PhylomeDB; G4LY66; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008854};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    237    254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    274    292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    375    396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    416    436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    443    465       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      547    651       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      670    697       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   801 AA;  92000 MW;  B535F7969A5973CC CRC64;
     MPEESKDATN KITQSQPVIS ISKESMEKAI AAFPQSKLNR TTTNASFLRI PQRNVRSDSE
     ISVSVVEKLR SLRTKFTERT ELIKAKEIEK VEISESDSDE KETGTDPTKS DENELKLDGE
     FKTTEIQKEK PIGWWKRYPN RKLIIRQPLC LTCLPSSRKY FISKPNLPCF SIQNPEDNEK
     QEQGEVKVVK VSEQEMEQPE IIGQECVKLK QISIPLPAWL VGLKDVFSAT ISPYSNIYLL
     WLGFLLIAVL YNYITIPLRE AFNIYDDEDN MTLWYTLNSL MDILYLMDIL LLKPRIEFLD
     QGITKTDFKS CALHYFKSLQ FKIDIISITP LDLFSLFYEK DMARFRVLRL VKINAFWEAF
     EKLDQRLNAG YAVRLARTII YMIYIIHLET CGYYAFNRWQ GIGETSWTIQ PGPISPYVYS
     FYVCMKTATS IGSLPAATNS SEFLFMTCYW LSGILVSAIL IGQVIDILDS ASANKVNYRK
     VMDATLSSMQ QLHAPQHVVD KVRSWFMYNW DQQKTFNENS LFECLPIKLK SDLAISVHFH
     TLSKVTLFQN CEKALIYDMI LKLKPVVFLP KDYICRKGEV GKEMYIVKSG AVEVVGGPNN
     SIVFVTLKEG SVFGEISLLA LSGKNRRTAD VRSKGFSTLF SLSKQDFEEI MKNYPQAHEL
     LKKRSQRMLN RDKKKATDEA VKEKKKLQKE KSNELNDGDV AVIEVIPERP ATPKLIETVV
     KVIESTYPDK IIARQLKGSF SSELGTRRRS IYTIKPSINM VTNKKSSIPN TNDDNTANYD
     EKIFLPEPIK KLINKQYFSL Y
//
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