ID   G4LYL7_SCHMA            Unreviewed;       379 AA.
AC   G4LYL7;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Subfamily C14A unassigned peptidase (C14 family) {ECO:0000313|WBParaSite:Smp_032000.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854, ECO:0000313|WBParaSite:Smp_032000.1};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of the
RT   human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
RN   [2] {ECO:0000313|WBParaSite:Smp_032000.1}
RP   IDENTIFICATION.
RC   STRAIN=Puerto Rican {ECO:0000313|WBParaSite:Smp_032000.1};
RG   WormBaseParasite;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   RefSeq; XP_018646351.1; XM_018790330.1.
DR   AlphaFoldDB; G4LYL7; -.
DR   STRING; 6183.G4LYL7; -.
DR   EnsemblMetazoa; Smp_032000.1; Smp_032000.1; Smp_032000.
DR   GeneID; 8344650; -.
DR   KEGG; smm:Smp_032000; -.
DR   WBParaSite; Smp_032000.1; Smp_032000.1; Smp_032000.
DR   CTD; 8344650; -.
DR   eggNOG; KOG3573; Eukaryota.
DR   HOGENOM; CLU_036904_5_2_1; -.
DR   InParanoid; G4LYL7; -.
DR   OMA; VMVLMTH; -.
DR   OrthoDB; 2960676at2759; -.
DR   PhylomeDB; G4LYL7; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd01671; CARD; 1.
DR   CDD; cd00032; CASc; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR   PANTHER; PTHR47901:SF8; CASPASE-3; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PIRSF; PIRSF038001; Caspase_ICE; 2.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00114; CARD; 1.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854}.
FT   DOMAIN          1..91
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   DOMAIN          135..261
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          289..376
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
SQ   SEQUENCE   379 AA;  42906 MW;  54DF981E0FD69986 CRC64;
     MEKEHRDVIR KLRVFLVKNI SNLEEILDIL ESSLIITENQ RHSILSGVTL AEKIRRFLDV
     IVRCGPLAYD RFKQALLETN QKSIYDLLNE TEELKVVTGH GMSSECLSDA KDESIMIPDR
     VSSHPLIPYT VTSFPRGYVL IINIEDYSRE SGVPNRHGSS HDASKLQILF EDFMYSVAVI
     KNLEGEKLKK VVREFACKPE HSNVHAAVLI ILAHGLEHHI IASDGIHVSI DELVGCFTNK
     RCPLLAGKPK LILIQACRGE ERNHNGLVKR DFQDSLLSNS CEVSLDPSSW LSLPHMSDCV
     IVYSTLPGFV SWRSEIEGSW YVKVFVEVTR LHGHRLHILE LLTEVNNRLV SEASNYGIKQ
     ISQPVTTLTK PYYLSTLKT
//