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Database: UniProt
Entry: G4NPA9_CHLT4
LinkDB: G4NPA9_CHLT4
Original site: G4NPA9_CHLT4 
ID   G4NPA9_CHLT4            Unreviewed;       205 AA.
AC   G4NPA9;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=Dephospho-CoA kinase {ECO:0000256|HAMAP-Rule:MF_00376};
DE            EC=2.7.1.24 {ECO:0000256|HAMAP-Rule:MF_00376};
DE   AltName: Full=Dephosphocoenzyme A kinase {ECO:0000256|HAMAP-Rule:MF_00376};
GN   Name=coaE {ECO:0000256|HAMAP-Rule:MF_00376};
GN   OrderedLocusNames=CTO_0539 {ECO:0000313|EMBL:AEP35355.1};
OS   Chlamydia trachomatis serovar A (strain A2497).
OC   Bacteria; Chlamydiota; Chlamydiia; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=580047 {ECO:0000313|EMBL:AEP35355.1, ECO:0000313|Proteomes:UP000009287};
RN   [1] {ECO:0000313|EMBL:AEP35355.1, ECO:0000313|Proteomes:UP000009287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A2497 {ECO:0000313|EMBL:AEP35355.1,
RC   ECO:0000313|Proteomes:UP000009287};
RX   PubMed=21987657; DOI=10.1084/jem.20111266;
RA   Kari L., Whitmire W.M., Olivares-Zavaleta N., Goheen M.M., Taylor L.D.,
RA   Carlson J.H., Sturdevant G.L., Lu C., Bakios L.E., Randall L.B.,
RA   Parnell M.J., Zhong G., Caldwell H.D.;
RT   "A live-attenuated chlamydial vaccine protects against trachoma in nonhuman
RT   primates.";
RL   J. Exp. Med. 208:2217-2223(2011).
CC   -!- FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group of
CC       dephosphocoenzyme A to form coenzyme A. {ECO:0000256|HAMAP-
CC       Rule:MF_00376}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+);
CC         Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216;
CC         EC=2.7.1.24; Evidence={ECO:0000256|HAMAP-Rule:MF_00376};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 5/5. {ECO:0000256|HAMAP-Rule:MF_00376}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00376}.
CC   -!- SIMILARITY: Belongs to the CoaE family. {ECO:0000256|HAMAP-
CC       Rule:MF_00376}.
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DR   EMBL; CP002401; AEP35355.1; -; Genomic_DNA.
DR   AlphaFoldDB; G4NPA9; -.
DR   KEGG; cra:CTO_0539; -.
DR   PATRIC; fig|580047.4.peg.545; -.
DR   OMA; VTEIWVV; -.
DR   UniPathway; UPA00241; UER00356.
DR   Proteomes; UP000009287; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd02022; DPCK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR   PANTHER; PTHR10695:SF46; BIFUNCTIONAL COENZYME A SYNTHASE-RELATED; 1.
DR   PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR   Pfam; PF01121; CoaE; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00376}; Coenzyme A biosynthesis {ECO:0000256|HAMAP-Rule:MF_00376};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00376};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00376, ECO:0000313|EMBL:AEP35355.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00376}; Transferase {ECO:0000256|HAMAP-Rule:MF_00376}.
FT   BINDING         17..22
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00376"
SQ   SEQUENCE   205 AA;  23238 MW;  BDA560EED60AD290 CRC64;
     MGGMLDLLKI SVTGDPSSGK TEACQVFEDL GAYVISADKV SHSFLVPYTS VGQRIIDLLG
     PEIIIENTLS RKAIAEKVFG NRDLLLSLEE ILHPEVCRFV DEKYAYVVQE QKYPLFIAEF
     PLLYEIQYAD WFDQVILISA DKGIRKERFL KKTGGSDTSF DLRCARFSSL EEKILRADVV
     IENNGTKEEF RRKVKQCFKA LKGTI
//
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