ID G4Q662_ACIIR Unreviewed; 871 AA.
AC G4Q662;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:AEQ22163.1};
GN OrderedLocusNames=Acin_0934 {ECO:0000313|EMBL:AEQ22163.1};
OS Acidaminococcus intestini (strain RyC-MR95).
OC Bacteria; Bacillota; Negativicutes; Acidaminococcales; Acidaminococcaceae;
OC Acidaminococcus.
OX NCBI_TaxID=568816 {ECO:0000313|EMBL:AEQ22163.1, ECO:0000313|Proteomes:UP000007093};
RN [1] {ECO:0000313|EMBL:AEQ22163.1, ECO:0000313|Proteomes:UP000007093}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RyC-MR95 {ECO:0000313|EMBL:AEQ22163.1,
RC ECO:0000313|Proteomes:UP000007093};
RX PubMed=22123762; DOI=10.1128/JB.06301-11;
RA D'Auria G., Galan J.C., Rodriguez-Alcayna M., Moya A., Baquero F.,
RA Latorre A.;
RT "Complete genome sequence of Acidaminococcus intestini RYC-MR95, a Gram-
RT negative bacterium from the phylum Firmicutes.";
RL J. Bacteriol. 193:7008-7009(2011).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096}.
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DR EMBL; CP003058; AEQ22163.1; -; Genomic_DNA.
DR RefSeq; WP_014128370.1; NC_016077.1.
DR AlphaFoldDB; G4Q662; -.
DR STRING; 568816.Acin_0934; -.
DR KEGG; ain:Acin_0934; -.
DR PATRIC; fig|568816.4.peg.903; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_9; -.
DR InParanoid; G4Q662; -.
DR Proteomes; UP000007093; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000007093}.
FT DOMAIN 693..709
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 619..626
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 871 AA; 97713 MW; 07F084791C51F0E3 CRC64;
MTQTGEGYTP MVQQYMEIKK QHEDKLLFYR LGDFYELFFG DAITASRELN LTLTQRAGNT
KHPIPMCGVP FHSVDGYLAK LIKKGYRIAI CDQMEDPKKA VGIVKREVTK ILTPGTVLSD
AVLDDEHNQY LAAVSIGDGR AVLGLADVST GEASWYEASG PYWEDLLMDQ IYRMQPAELV
LAPDEQLPER FLQELSQKLP QCMVNRFQKD GGIDAFARHF GTEGKAYTEP LVRDTIELML
QYIHINVKSD LAQLNRLTEI TTDRTMVLDA TAIRNLELVR NMKDGTKKGT LLDILDYTAT
AMGARLMRQW IESPLYDAAR ITSRQQAVGT LVGDSRLRTE LGEALKKITD LERILSRIEV
GSANARDMAS LRTALLAVPD LKRLLAPYRD GLLAKLSSRI DSHETVLDEL RRGIVDDPPF
TVREGGMIRK GYNAELDELH DIAENNNAWM QDFELRIKEE TGIKNLKVGF NKVFGYYIEV
SKGQVSQVPD SFIRKQTLVN GERYIVPELK AFENKILSAK EKIQQLEYYL FNEIRDCVRD
ELVTIQDTAR AIGELDAIYS LAMAAFKGNY VCPRLSDKGE IIIKDGRHPV VEKLLERELF
VPNDVHLNGT NERLIILTGP NMAGKSTYMR QVALLVLMTQ MGSFLPCREA VITPVDRIFT
RVGASDDLAT GQSTFMVEMN EVANILKNAT SRSLIILDEV GRGTSTYDGM SIARAVVEYI
NEKIKAKTLF ATHYHELIEL EDLFDGIKNY SIAVKEKGND VVFLRRIVPG GTDRSYGIHV
AKLAGLPKKV LDRADELLEE YAAEAPLSHK GTHHVEISKE AATDETQGSL FGDTIRDTLM
GLDVMTMTPL EAMNTLYQLA EEAKREGGKL S
//
