ID G4SY11_META2 Unreviewed; 1062 AA.
AC G4SY11;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=MEALZ_2637 {ECO:0000313|EMBL:CCE24312.1};
OS Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM
OS B-2133 / 20Z) (Methylomicrobium alcaliphilum).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylotuvimicrobium.
OX NCBI_TaxID=1091494 {ECO:0000313|EMBL:CCE24312.1, ECO:0000313|Proteomes:UP000008315};
RN [1] {ECO:0000313|Proteomes:UP000008315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z
RC {ECO:0000313|Proteomes:UP000008315};
RX PubMed=22207753; DOI=10.1128/JB.06392-11;
RA Vuilleumier S., Khmelenina V.N., Bringel F., Reshetnikov A.S., Lajus A.,
RA Mangenot S., Rouy Z., Op den Camp H.J., Jetten M.S., Dispirito A.A.,
RA Dunfield P., Klotz M.G., Semrau J.D., Stein L.Y., Barbe V., Medigue C.,
RA Trotsenko Y.A., Kalyuzhnaya M.G.;
RT "Genome sequence of the haloalkaliphilic methanotrophic bacterium
RT Methylomicrobium alcaliphilum 20Z.";
RL J. Bacteriol. 194:551-552(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FO082060; CCE24312.1; -; Genomic_DNA.
DR RefSeq; WP_014149080.1; NC_016112.1.
DR AlphaFoldDB; G4SY11; -.
DR STRING; 1091494.MEALZ_2637; -.
DR KEGG; mah:MEALZ_2637; -.
DR PATRIC; fig|271065.3.peg.2705; -.
DR HOGENOM; CLU_288990_0_0_6; -.
DR Proteomes; UP000008315; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 4.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 4.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR007895; MASE1.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 4.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF05231; MASE1; 1.
DR Pfam; PF08448; PAS_4; 2.
DR Pfam; PF13188; PAS_8; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 4.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 4.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 3.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000313|EMBL:CCE24312.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008315};
KW Transferase {ECO:0000313|EMBL:CCE24312.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 367..420
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 421..463
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 621..672
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 666..741
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 745..797
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 835..1049
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 1062 AA; 121386 MW; 60AA904A98E2E3C7 CRC64;
MKLFNTRFCL DILSIFGLYF FFVKLSDLFA GTFANQEMIW FPSGFALAYM LIRGASSAVL
IVCSAFVTHI VSGADIIPSL FWALGNTLEP LLGLALLRRI NFDPRLVDIK SYYVLLIFGA
GVASICAASL NILVWIVLNG LTLEEYGAWA SSTWLSHTLG IMLLTPLILI FYYQRHGFTL
KQRKLEFVLF LLLTLILERL SAFSLTQHWQ TAQFESFWMF LLMIFTALRL GRHGVSIGLL
IIVLSCGLRV ESHHPIDLSY LDFWLHHMAL VICSMTLAIA LYEQRFTEKK FDSEAIKYKT
LVNMLPDMVW LKDPQLNYLA CNQAFERFLQ NSCDSIIGKN DHALFEKWLA DHYRESDQRT
LTMREPLFLQ EQLQHREQGD ERHLEIVKTP IFGTDGKLIS LLGVARDVTD FVNTSNELKA
SEARAHAIIE ATPVPMALSG DRGRILYVNP AFKRTFGYDP SDVQTVDDWW ARAIPDEAKR
QEAIGKWRNL LNRTEFEHSD VIDREISIQD KSAATHQVLL TVSRVNRNDC LMVLFDITEH
KRLRKNNSRF YRSIAASINE IYIFEAESLR FSFVNAGALA NLGYSMAELK KITPLDIKPA
YSLTDFNRLI EPLKRHEKPG QLFETVHRRK DGSLYDVEVH LQLFEPIDEP PYFLAIVLDI
TEIKQLEAKM STLVDAVNAI IWSIDADLRI DYVSQQALQI LGFDTTAIIG KPIISVLESD
RFHAAERPVL LKAFQELLEK HVPIKNLEHR IKDANDQWKW MAVSMTPILD ANHALQKIVG
VVHDLSLQKR AEEQLRSLNS ELDRRVRQEV FANRKKDLLL QQQNRMAALG EMIGNIAHQW
RQPLNALAII LMDLEDAFVH GEATAETIRH SIDRSNELLS KMSSTIDDFR NFFKNDKTLE
KTEISQVVTE TLGLLEATLT LSHIQLHVTE KIPGITGYIH AGELSQAILC LINNAKDQIV
KKQMVQGLIY VEIDTDDDWC IIRVEDNGGG IAEHDWPKLF DPYFTTKPQG SGLGLYITKL
TVEQSMHGRV LVENTDLGAR FSLFLPKHPN MELFRWTEPN NP
//
