ID G4SZ41_META2 Unreviewed; 658 AA.
AC G4SZ41;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Glutathione-regulated potassium-efflux system protein {ECO:0000313|EMBL:CCE22191.1};
GN Name=kefB {ECO:0000313|EMBL:CCE22191.1};
GN OrderedLocusNames=MEALZ_0493 {ECO:0000313|EMBL:CCE22191.1};
OS Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM
OS B-2133 / 20Z) (Methylomicrobium alcaliphilum).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylotuvimicrobium.
OX NCBI_TaxID=1091494 {ECO:0000313|EMBL:CCE22191.1, ECO:0000313|Proteomes:UP000008315};
RN [1] {ECO:0000313|Proteomes:UP000008315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z
RC {ECO:0000313|Proteomes:UP000008315};
RX PubMed=22207753; DOI=10.1128/JB.06392-11;
RA Vuilleumier S., Khmelenina V.N., Bringel F., Reshetnikov A.S., Lajus A.,
RA Mangenot S., Rouy Z., Op den Camp H.J., Jetten M.S., Dispirito A.A.,
RA Dunfield P., Klotz M.G., Semrau J.D., Stein L.Y., Barbe V., Medigue C.,
RA Trotsenko Y.A., Kalyuzhnaya M.G.;
RT "Genome sequence of the haloalkaliphilic methanotrophic bacterium
RT Methylomicrobium alcaliphilum 20Z.";
RL J. Bacteriol. 194:551-552(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FO082060; CCE22191.1; -; Genomic_DNA.
DR RefSeq; WP_014147000.1; NC_016112.1.
DR AlphaFoldDB; G4SZ41; -.
DR STRING; 1091494.MEALZ_0493; -.
DR KEGG; mah:MEALZ_0493; -.
DR PATRIC; fig|271065.3.peg.509; -.
DR HOGENOM; CLU_005126_9_0_6; -.
DR Proteomes; UP000008315; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR46157; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR46157:SF4; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000008315};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 414..536
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 575..658
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 658 AA; 71843 MW; FC6988BFAE9FB2D6 CRC64;
MIEQAFVQIL LMLGTSVAAV ILFQKLHIPS SLGYLMVGVL FGAHTPGPVI DVQQIREVAE
FGIVFLLFTI GLSFSLPQIH ALRGQVLSLG TGQVVLTTAL IGTGCWLLGL PPATSFVIGA
VFAQSSTTII SKQLAEQGEE NSRHGRLGVA MSVFQDVTAV PLIVVIPVLG VLDDDAGVLF
ESLGWAMAKA IVAFLLVFML GRWLLRPLFH SVAARRSTEL FTLTVLFVSL LAAWTTSQLG
LSMAFGAFLV GMMLGETEFR HQVESTIRPF RDVLIGLFFV SIGMLFDPAA IPQNWQWATI
GTIAMLVSKT VLVALIVRWS GLDGLTAWRT GFLLAVGGEF GFALLAIALD VNAIANQYSQ
IVFTSVLFSM IVAPFLIRYN HVLAGLLVRR SVRRQNDPET LPVSADATQH LHDHAIICGY
GRIGQSVGHF LEEEKIPYVA VDLDSARIKE AHVAGEPVYY GDSSERDILE ALGIDSAKLL
VISYDDVLLA KKILHHVRAL RPDLPVMVRT RDEAHVDELR QAGATEVVPE VLEAGLMIAS
HALLLLNVPF KRVVRRMQQQ RAGRYRLLRE LYRGEDVFSD NPNILTEDGL RSVLMLPGSR
GIGKKLSEFA FDGVTVSSLV RQGSREEDPL DVFIVEGDVV VLFGAPGTLD RAERLLLG
//
