ID G4T084_META2 Unreviewed; 712 AA.
AC G4T084;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=PLD phosphodiesterase domain-containing protein {ECO:0000259|PROSITE:PS50035};
GN OrderedLocusNames=MEALZ_1687 {ECO:0000313|EMBL:CCE23374.1};
OS Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM
OS B-2133 / 20Z) (Methylomicrobium alcaliphilum).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylotuvimicrobium.
OX NCBI_TaxID=1091494 {ECO:0000313|EMBL:CCE23374.1, ECO:0000313|Proteomes:UP000008315};
RN [1] {ECO:0000313|Proteomes:UP000008315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z
RC {ECO:0000313|Proteomes:UP000008315};
RX PubMed=22207753; DOI=10.1128/JB.06392-11;
RA Vuilleumier S., Khmelenina V.N., Bringel F., Reshetnikov A.S., Lajus A.,
RA Mangenot S., Rouy Z., Op den Camp H.J., Jetten M.S., Dispirito A.A.,
RA Dunfield P., Klotz M.G., Semrau J.D., Stein L.Y., Barbe V., Medigue C.,
RA Trotsenko Y.A., Kalyuzhnaya M.G.;
RT "Genome sequence of the haloalkaliphilic methanotrophic bacterium
RT Methylomicrobium alcaliphilum 20Z.";
RL J. Bacteriol. 194:551-552(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000798};
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DR EMBL; FO082060; CCE23374.1; -; Genomic_DNA.
DR RefSeq; WP_014148167.1; NC_016112.1.
DR AlphaFoldDB; G4T084; -.
DR STRING; 1091494.MEALZ_1687; -.
DR KEGG; mah:MEALZ_1687; -.
DR PATRIC; fig|271065.3.peg.1729; -.
DR HOGENOM; CLU_011094_0_0_6; -.
DR Proteomes; UP000008315; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006793; P:phosphorus metabolic process; IEA:UniProt.
DR CDD; cd09140; PLDc_vPLD1_2_like_bac_1; 1.
DR CDD; cd09143; PLDc_vPLD1_2_like_bac_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR015679; PLipase_D_fam.
DR InterPro; IPR032816; VTT_dom.
DR PANTHER; PTHR18896:SF76; PHOSPHOLIPASE; 1.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR Pfam; PF00614; PLDc; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR Pfam; PF09335; SNARE_assoc; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008315};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..153
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 344..371
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 712 AA; 80357 MW; 5EF9C88CFEADA215 CRC64;
MKTIFQSENC WRIEKAHRAA FVIDGENYFR ALHEALQKAR RSIMIVGWDL HSELRLIRNG
ETAELPEDLG KLLDFLVKRN PGLQIYVLSW DFAMIYAMER EFFPRYKLLW STHKQVRFYL
DGEHPVGASQ HMKIVVIDDA IAFAGGLDLS KWRWDTSEHL PDDKRRIDPD GEAYPPFHDI
QMIVDGPAAQ ALGELAGERW RRAYGEAPLI DERIEIVDPW PESVKADFHD VEIAIARTWP
AYRDYAEVRE VERLYLDTIA AARKLIYIEN QYLSSFRIGE ALTARLQETD GPEVIIVQPK
KTGGWLEQHT MDVLRGRILF KLREADRHRR LHVYYPRISV DPEVDLMVHA KVMVIDDCFV
RVGSSNLSNR SLGFDSECDL AIAAEEGSPE SKAISAFRNG LLAEHLGTEI EQVANAYHET
GTLAGAIESL SKGERRLVKL DGAIPDEVDQ WVPESELLDP EQPLEPEELF EYLIGPKQQL
PVFRHMLKNV LLIAIFLIIA ALWRWADLGE YSVFDTIEAA ALWLQQQNYT FLLIPFLYFA
GGLCFFPVTV LLIATVLLFG PWQGFLYALI GSELSAVSLF LIGRRLGRDK VSRLSGDLLN
SLTRKFSESG LKSVIFFRIF PVASFSIVNL IAGVSKIRLY DFALGTMIGL LPALSVLVIV
AYGITVAIHD SGSSYFVGLM IAIALSSVAL FFFLGRLRKK YGKGASGGSG SI
//
