ID G4T1H2_META2 Unreviewed; 1688 AA.
AC G4T1H2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:CCE22394.1};
GN OrderedLocusNames=MEALZ_0699 {ECO:0000313|EMBL:CCE22394.1};
OS Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM
OS B-2133 / 20Z) (Methylomicrobium alcaliphilum).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylotuvimicrobium.
OX NCBI_TaxID=1091494 {ECO:0000313|EMBL:CCE22394.1, ECO:0000313|Proteomes:UP000008315};
RN [1] {ECO:0000313|Proteomes:UP000008315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z
RC {ECO:0000313|Proteomes:UP000008315};
RX PubMed=22207753; DOI=10.1128/JB.06392-11;
RA Vuilleumier S., Khmelenina V.N., Bringel F., Reshetnikov A.S., Lajus A.,
RA Mangenot S., Rouy Z., Op den Camp H.J., Jetten M.S., Dispirito A.A.,
RA Dunfield P., Klotz M.G., Semrau J.D., Stein L.Y., Barbe V., Medigue C.,
RA Trotsenko Y.A., Kalyuzhnaya M.G.;
RT "Genome sequence of the haloalkaliphilic methanotrophic bacterium
RT Methylomicrobium alcaliphilum 20Z.";
RL J. Bacteriol. 194:551-552(2012).
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DR EMBL; FO082060; CCE22394.1; -; Genomic_DNA.
DR STRING; 1091494.MEALZ_0699; -.
DR KEGG; mah:MEALZ_0699; -.
DR PATRIC; fig|271065.3.peg.713; -.
DR HOGENOM; CLU_000445_34_2_6; -.
DR Proteomes; UP000008315; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CCE22394.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008315};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:CCE22394.1};
KW Transferase {ECO:0000313|EMBL:CCE22394.1}.
FT DOMAIN 7..268
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1550..1687
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT COILED 1464..1522
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1688 AA; 190349 MW; 50592EE3A3E7A411 CRC64;
MLQIDEYLIK ECLSDRGWYR LYRAVRVQDR KEVTLKHLEE SHPSDTMLAC FRSEFDMLKR
VAMPAVTEGL DLLNHGRRLI LVREYFNGRT LREYAAGLAL PVQEAFGLIF ELIESIAAIH
RHGVVHGNLN PTNILVDPKQ MQLKLLGFGR AACALQTRAE PEALYPSERE IDYLAPEQSG
RMNRGIDGRA DIYGLGTIVF ELFTGRKPFM SPDSIGAIHR HIAHEVPDPR EFCPDLPDDL
ARIVIGMLAK DPEERYQRAD ELLSDLSLCR QALCKGQSME RTMPSVFRNP RQLYGREAEL
GQLEAALTQA RHDKAVLCLV TGPSGVGKSR LIESFNQQSL PADCYFISAK CDQFQNNPPA
RLFHDAFSLL LKQILGEEDE ALAIWRHRLF EQLGDEAAAV IELIPELELL LGAQPALAEL
PAAENKVRSL RLWLRFVQIF CRPNRPLCVF LDDLQWADPA LFEWLAAMLS GLEHLLLIAA
YRGDEVNPGD GVIALENKFR DEGGRVETIE LNALPMPALT AMMIDSIRLE KKTADELCAS
IHVKTQGNPF FFLQYLRELQ RNNVLHYDAG TGQWRFDRER LCAAAISDNV VDFMTKRVGK
LDEPVRELLK IVACIGCAVD PDTIVTVFGE NTLPYKNLAA AETLGLLLKQ SDMAEKNKAR
YFFSHDRVQQ AVHSLCSEHE LLGNRLKIGR FWVDQARMGH DRSLLSQAVD HLNATLPLID
DAGERSRLGA DNFKLGLWTK HRGAFEQALP YLRHASELLA DRLPSFGGLA SVLWQLAECE
HLCGHHKQAE RLFEQAVTLS RSELEKARIF ELMIQFYADL GRFDRAYRVG RQAAALFGID
LPKRFNRLSF LTEFLALKFR LRKFTTDDLL DLPAVADARM DIAIRLLSAT LKVAYQIRPE
LCAAISVKQV RRCLKHGNNA EAVIGYMVFG VIFLGGVLGN HQAGYDYGRL SLSLLDKYAN
QRQKAEVNFV YGYFANSWTH PAVDTETYWH TALDAGLESG DWFHSGCACC GLIQSQLMRG
VPLDVIWQES ERLLAILKRI DGREHSGVIE GIRQAIRNLR GDTDAPTSFG SADFDETTFV
EALADYGSRH FAHYYYVNKM QSLYLWGDDE RAMGTSRDSS AYLKDSAGML HAAEHHFYTA
LILAKRYPAM PRIERFRTLW IILRTEKNFR RWARRCPQNF QSRLFLLQAE IYRLQRKPAP
AALACQQAAS DAELNGQLHL EGLANELAGR LYREQGQERL ARFHFEEAAY CYRRWGATGY
LPHFNERYGL TLANRAGSPP HDIGHRWDLE TLLKAAETIA AERRLPDLLQ TLMNIVIENA
GAQRGVLLLQ ESGGLFVQAE ARIDSKDIEL MQRLPLAFAS DLPQTAINYV SRSRETVILD
NAGKSPVYGR DKVIIERRVR SLLCTPLLLS GELQGVLYLE NNAADAVFTE EHVFLLRHLS
GQIAISIDNA QGYRLLEDKV SERTKHIEKQ KAALKEKNSE LEARNATIEA LNERLLNENR
VRRLAEADLQ KANEELQRLA TMDSLTQIAN RRCFDDYLAQ ECRRLERDNA PLALILCDID
HFKLFNDRYG HQAGDECLIK VAQAIAGALR RPTDLAARYG GEEFAVVMPR TGAPGALQVG
KLIQQAVADL QIPHLGSEAT GFVTVSIGIA TATPFHKCPP ESLIKAADAA LYRVKENGRN
DIDLQSAA
//
