ID G4U2N9_SERID Unreviewed; 244 AA.
AC G4U2N9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Kinetochore protein SPC25 {ECO:0000256|RuleBase:RU367150};
GN ORFNames=PIIN_00507 {ECO:0000313|EMBL:CCA77861.1};
OS Serendipita indica (strain DSM 11827) (Root endophyte fungus)
OS (Piriformospora indica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Sebacinales; Serendipitaceae; Serendipita.
OX NCBI_TaxID=1109443 {ECO:0000313|EMBL:CCA77861.1, ECO:0000313|Proteomes:UP000007148};
RN [1] {ECO:0000313|EMBL:CCA77861.1, ECO:0000313|Proteomes:UP000007148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11827 {ECO:0000313|EMBL:CCA77861.1,
RC ECO:0000313|Proteomes:UP000007148};
RX PubMed=22022265; DOI=10.1371/journal.ppat.1002290;
RA Zuccaro A., Lahrmann U., Guldener U., Langen G., Pfiffi S., Biedenkopf D.,
RA Wong P., Samans B., Grimm C., Basiewicz M., Murat C., Martin F.,
RA Kogel K.H.;
RT "Endophytic Life Strategies Decoded by Genome and Transcriptome Analyses of
RT the Mutualistic Root Symbiont Piriformospora indica.";
RL PLoS Pathog. 7:e1002290-e1002290(2011).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU367150}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367150}.
CC Chromosome, centromere, kinetochore {ECO:0000256|RuleBase:RU367150}.
CC -!- SIMILARITY: Belongs to the SPC25 family.
CC {ECO:0000256|ARBA:ARBA00006379, ECO:0000256|RuleBase:RU367150}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCA77861.1}.
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DR EMBL; CAFZ01001876; CCA77861.1; -; Genomic_DNA.
DR AlphaFoldDB; G4U2N9; -.
DR STRING; 1109443.G4U2N9; -.
DR eggNOG; KOG4657; Eukaryota.
DR HOGENOM; CLU_093947_0_0_1; -.
DR InParanoid; G4U2N9; -.
DR OMA; HEDQRMK; -.
DR OrthoDB; 2727887at2759; -.
DR Proteomes; UP000007148; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR Gene3D; 3.30.457.50; Chromosome segregation protein Spc25; 1.
DR InterPro; IPR045143; Spc25.
DR InterPro; IPR013255; Spc25_C.
DR PANTHER; PTHR14281:SF0; KINETOCHORE PROTEIN SPC25; 1.
DR PANTHER; PTHR14281; KINETOCHORE PROTEIN SPC25-RELATED; 1.
DR Pfam; PF08234; Spindle_Spc25; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU367150};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU367150};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU367150};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367150};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU367150};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU367150};
KW Nucleus {ECO:0000256|RuleBase:RU367150};
KW Reference proteome {ECO:0000313|Proteomes:UP000007148}.
FT DOMAIN 171..238
FT /note="Chromosome segregation protein Spc25 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08234"
FT COILED 54..162
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 244 AA; 28275 MW; 47CBFC5E0A928CED CRC64;
MGNPFSSFNL NQVLDMDQPH IDINLPLLEK RMAVFKSSLG KYTTINQQEV INRRNLHLQE
IEKLRVERAQ IERDIQNYRM KEIALIQQLE AEKRERGNAE ESVAHSNRQL RTLQERMAEA
EQDAIRLDTV LKNLKNSKEK EKRQLEKQAS QIGRDVLELE QLLGIQVQGA GNDILTIKFK
RLDPRDPDRT FSVTIDLSSS EYRVTEVSPV LPGLPTLLDS LNESKDLFAF LRRIRQAFLN
SLEI
//
