ID G4U6J9_NEUT9 Unreviewed; 742 AA.
AC G4U6J9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=RhoGAP-domain-containing protein {ECO:0000313|EMBL:EGZ76558.1};
GN ORFNames=NEUTE2DRAFT_77108 {ECO:0000313|EMBL:EGZ76558.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ76558.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ76558.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
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DR EMBL; GL890999; EGZ76558.1; -; Genomic_DNA.
DR AlphaFoldDB; G4U6J9; -.
DR STRING; 510952.G4U6J9; -.
DR eggNOG; KOG1450; Eukaryota.
DR HOGENOM; CLU_010730_3_0_1; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07652; F-BAR_Rgd1; 1.
DR CDD; cd04398; RhoGAP_fRGD1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF138; RHO GTPASE ACTIVATOR; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000008513};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 36..312
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 545..738
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..516
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 80742 MW; D92918C0DD7F324C CRC64;
MSLGDASAPA TSPTPDSGSP VIAAAPAPPT APTSNDETKS HVQDVLSSEI GIATMLNRLK
QSIASAKEFA TFLKKRSVLE DEHANGLRKL CKASHESSSR SEHRGGTFAK AYEDMMTIHE
RMAENGTQFA MSLHQMHEDL LELAGIAEKS RKGWKQSGLT AEQRVADLEA AMRKSKAKYD
ALAEEYDRAR TGDTTGQQKG KMFGFKGPKS AAQHEEDLLR KAQAADQDYQ AKVNTVQTER
GELINKIRPD TIKALQEIVR ECDAGVVLQM QKFASFNEKL LLSNGLSVSP LKHGPEARSL
RECVQAINND KDLDEYLLSQ YPRLPPRTGE PKYEKNALLD PANRTTTTPY VPPGGSQQAP
THSREQGSMN SRTGPLNDTP TAPLGHHYGQ SSSSIPIISA SQQSESQPSH ERSFSHGNIL
NQISTPFNPQ YGDSRSAATQ QAQAASSRYN GAIGSISSSG PPQLGALPFQ YSQPQSPPST
TRQPPQQPSQ PPPPQPSQQP PSSQPPQQPP APLASPTQQA YPSGPVQGRQ STPPMAQPTR
PVFGVSLLKL YERDGLAVPM VVYQCIQAVD LFGLGLEGIY RLSGSVPHVN KLKTLFDTDS
GSSNLDFRNP ENFFHDVNSV AGLLKQFFRD LPDPLLTKEH YASFIEAAKN EDEVIRRDSL
HAIINSLPDP NYATLRALTL HLHRVINNSS VNRMSSQNLA IVFGPTLMGT AGPGANIADA
GWQVRVVDTI LQNTYQIFDD DD
//
