ID G4UGZ6_NEUT9 Unreviewed; 1548 AA.
AC G4UGZ6;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=PP2C-domain-containing protein {ECO:0000313|EMBL:EGZ74588.1};
GN ORFNames=NEUTE2DRAFT_163591 {ECO:0000313|EMBL:EGZ74588.1};
OS Neurospora tetrasperma (strain FGSC 2509 / P0656).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=510952 {ECO:0000313|EMBL:EGZ74588.1, ECO:0000313|Proteomes:UP000008513};
RN [1] {ECO:0000313|EMBL:EGZ74588.1, ECO:0000313|Proteomes:UP000008513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain FGSC 2509 / P0656 {ECO:0000313|Proteomes:UP000008513};
RX PubMed=21750257; DOI=10.1534/genetics.111.130690;
RA Ellison C.E., Stajich J.E., Jacobson D.J., Natvig D.O., Lapidus A.,
RA Foster B., Aerts A., Riley R., Lindquist E.A., Grigoriev I.V., Taylor J.W.;
RT "Massive changes in genome architecture accompany the transition to self-
RT fertility in the filamentous fungus Neurospora tetrasperma.";
RL Genetics 189:55-69(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the PP2C family.
CC {ECO:0000256|RuleBase:RU003465}.
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DR EMBL; GL891107; EGZ74588.1; -; Genomic_DNA.
DR STRING; 510952.G4UGZ6; -.
DR eggNOG; ENOG502QURR; Eukaryota.
DR HOGENOM; CLU_246490_0_0_1; -.
DR Proteomes; UP000008513; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR006644; Cadg.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015655; PP2C.
DR InterPro; IPR000222; PP2C_BS.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR13832:SF565; AT28366P-RELATED; 1.
DR PANTHER; PTHR13832; PROTEIN PHOSPHATASE 2C; 1.
DR Pfam; PF05345; He_PIG; 3.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00736; CADG; 2.
DR SMART; SM00331; PP2C_SIG; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF49313; Cadherin-like; 3.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS01032; PPM_1; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003465};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912,
KW ECO:0000256|RuleBase:RU003465};
KW Reference proteome {ECO:0000313|Proteomes:UP000008513};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1548
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003469668"
FT TRANSMEM 465..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1132..1404
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 432..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1440..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1499..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1440..1456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1504..1521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1548 AA; 166211 MW; 7AF90F526E1FF920 CRC64;
MASLLRLLAS LLFVAVSNAA PGVYFPISSQ IPPIARIGEP FSFIFSKSTF TSTTSITYSL
ANSPHWLSID SDARKLYGTP KEADVGLGDR VNVPFGLVAT DETGSTTLDI TLVVSRKAGP
KLDIPFNQQI PGFGFFSNPY TILSPPMNQF SFVLDPKTFS VPSDKPLTYY AVMSDNTPLP
AWISFDAGKL AFSGQTPAFE ALVDPPQTFE FQLLATDTPG FADASLRFNI VVGNHRVTAD
QTTVVINATA GKSFSYDGLR GNIDVDGQPM PSGDGIIVVS TFNTPSWLTL DMDSLHITGT
PPLTAKSTNF TLTLEDSFAD RFNLTVMVQV SGTQAQIFGM LKEELPVIQA HAGEHISFEL
DPFLKDPDGT EIVVDDDTSP SWIRVREGTI FGDVPKSSKD SIVSATIRLT SKASGASESV
LLSVHMLADT GDAVDTTDTD STPGSTSTGD LGGTKPTQKH APTPIGLILL VTILPGLLLL
GALMGMLVCC LRRRREAKRP KLSTRDIPGP LPGTFTINVT GPDGQSSMEH ITGPYNTQST
ISQMSLAEQD RKSDPESGIS RHQSFDADVP RPLSTVRMLP TNEELLPASS SLLDITGSPL
MSGAITGTPR NRRHERTQTL LSHISETSYY EEHSSGITIE NTLEFLGNSN TRGSFRDGVE
VDIPCLGDLS SIQPTPNSAY TGESYWSKLG SGPSVHNRSP AIGSVHNDPT GAARTQPAML
VRKLVWPWFK GRVISIKGVA EKFGEAAKTT LAGLPSLSSV QASLHDKTPD ISLLSNKQSE
SSDIPDFPSP PQGTKRPIMT KYARPVTRRA VGTGRIVIPR QRLVSTKVEV VGGPTEDLYK
PAEDKKQASP TSSFDRPSRN SLGISYADMA SNSPFHQSST WSTIPSSHEW HDETLQSLEN
ADSVLPSSSL RRSRSASQPN WAPYKDSLSN INDGASSKYP QSQWSFAPIP RPQPLGDASS
IASQGLSNSV SGHARAPTLS SVGFSKAPSS FRLDGNENTH TDDAEKENKW AGGTSGFLNA
HLHLSTRTGT LPLPGCTSIL PPAKEPNLAN NLLQSTPEQQ TTTCTSTVPF LDSKARSKFP
LSVTSLVADY SSTTPTPTPP PTTTHTDIIM GQTLSEPVVE KASATGGDER LIYGVSAMQG
WRISMEDAHT TVLDLLANNP KEAKDHSQKL SFFGVFDGHG GDKVALFAGA NIHDIIAKQD
TFKTGNYEQA LKDGFLATDR AILNDPKYEE EVSGCTACVG LITDDKIFVA NAGDSRSVLG
VKGRAKPLSF DHKPQNEGEK ARITAAGGFV DFGRVNGNLA LSRAIGDFEF KKSAELAPEQ
QIVTAYPDVM VHDLADDDEF LVLACDGIWD CQSSQAVVEF VRRGIAAKQD LDKICENMMD
NCLASNSETG GVGCDNMTMI IVGFLRGRTK EEWYEEIAKR VANGDGPCAP PEYAEFRGPG
VHHNFDDSDS GYDLEDNGNK GKPFGMGGYK GRIIFLGDGT EVLTDADDTE MFDNVEEDKD
LASQVSKSPS SITTNDQDQK EQAAVAAAAA DNSTQNAKKE ETSSPAKA
//