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Database: UniProt
Entry: G4V7J7_SCHMA
LinkDB: G4V7J7_SCHMA
Original site: G4V7J7_SCHMA 
ID   G4V7J7_SCHMA            Unreviewed;       865 AA.
AC   G4V7J7;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-SEP-2017, entry version 38.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Smp_040970.1 {ECO:0000313|EMBL:CCD75992.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of
RT   the human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE601624; CCD75992.1; -; Genomic_DNA.
DR   RefSeq; XP_018648866.1; XM_018794455.1.
DR   ProteinModelPortal; G4V7J7; -.
DR   STRING; 6183.Smp_040970.1__mRNA; -.
DR   EnsemblMetazoa; Smp_040970.1; Smp_040970.1:pep; Smp_040970.
DR   GeneDB; Smp_040970.1:pep; -.
DR   GeneID; 8343995; -.
DR   CTD; 8343995; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; G4V7J7; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   PhylomeDB; G4V7J7; -.
DR   Proteomes; UP000008854; Chromosome 1.
DR   ExpressionAtlas; G4V7J7; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008854};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    396    429       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    449    468       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    544    564       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    570    596       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    637    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    797    820       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    135       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   865 AA;  98400 MW;  2F62663A8415A5FF CRC64;
     MGSLFRSEEM QLSQMFLHTD IAYMCISELG ELGLVQFRDT VPGTNAFQRK FVNEVRRCDE
     MERKLRFLEK EIEKDKFPIL DTGENPEAPA PREIIDLESI FEKLENELKE VNSSAEKLKK
     TYLELSELKQ ILRKTQTFFD EALHDPAMSE ENVGLLGGEA MGAAGTAGGL RLGFLAGIIL
     RERLPAFERM LWRVCRGNVF LKQAEVDDPL EDLTTGMPVH KSVFLVFFQG DQLRTRVKKI
     CDGFHATLYP CPDSQADRRN MAIEVMGQIQ DLETVLTQTR QHRQRILETA AKNLRTWFIR
     VRKIKAIYHT LNLFNLDVTT KCMVGECWCA VNDVDKINLA LRRGMERSNS TLQPILNGIV
     TTENPPTYHR TNKFTYAFQS IIDAYGVARY REVNPALFTV ITFPFLFAVM FGDAGHGLLM
     FLFALWMVVC ERKLSANKSG GEIWNIFFSG RYIILLMGLF SIYTGLIYND IFSLSANIFG
     SSWYPTYDNS VLSKEVRLQL EPRTSVNVSD RMYAGYPYPF GLDPVWQLSG NKIMLTNSIK
     MKMSVVLGVL HMLLGISLGA FNYRNNKDNL SIWCLLLPQI LFLSCIFLYL VILIFFKWVA
     YTAETASSAP SLLIGLINMI RFSYSDEIPP LYSGQKAVQS ILMVVAVICV PWMLLSKPLI
     LYMRHRAILK NRHYVDPDAS VHVVVGGVTN PNMDDSFTGD NNGIMYSDMS PLHRSSSEKR
     SKVSLISQTD SPRSHDVHKF DFGDIMVHQS IHTIEFCLGC ISNTASYLRL WALSLAHAQL
     SEVLWSMVMR MGLRISGLYG GVVLAFIFAF WAVLTVSILL CMEGLSAFLH TLRLHWVEFQ
     NKFYSGDGYP FVPFTFEHSN SLVDN
//
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