GenomeNet

Database: UniProt
Entry: G4V7J8_SCHMA
LinkDB: G4V7J8_SCHMA
Original site: G4V7J8_SCHMA 
ID   G4V7J8_SCHMA            Unreviewed;       676 AA.
AC   G4V7J8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Smp_040970.3 {ECO:0000313|EMBL:CCD75993.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of
RT   the human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; HE601624; CCD75993.1; -; Genomic_DNA.
DR   RefSeq; XP_018648867.1; XM_018794456.1.
DR   ProteinModelPortal; G4V7J8; -.
DR   EnsemblMetazoa; Smp_040970.1; Smp_040970.1:pep; Smp_040970.
DR   EnsemblMetazoa; Smp_040970.3; Smp_040970.3:pep; Smp_040970.
DR   GeneDB; Smp_040970.3:pep; -.
DR   GeneID; 8343995; -.
DR   KEGG; smm:Smp_040970.1; -.
DR   CTD; 8343995; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; G4V7J8; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG091G01BI; -.
DR   PhylomeDB; G4V7J8; -.
DR   Proteomes; UP000008854; Chromosome 1.
DR   ExpressionAtlas; G4V7J8; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008854};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    207    240       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    260    279       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    355    375       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    381    407       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    448    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    608    631       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   676 AA;  76930 MW;  08BB71E108B04613 CRC64;
     MLWRVCRGNV FLKQAEVDDP LEDLTTGMPV HKSVFLVFFQ GDQLRTRVKK ICDGFHATLY
     PCPDSQADRR NMAIEVMGQI QDLETVLTQT RQHRQRILET AAKNLRTWFI RVRKIKAIYH
     TLNLFNLDVT TKCMVGECWC AVNDVDKINL ALRRGMERSN STLQPILNGI VTTENPPTYH
     RTNKFTYAFQ SIIDAYGVAR YREVNPALFT VITFPFLFAV MFGDAGHGLL MFLFALWMVV
     CERKLSANKS GGEIWNIFFS GRYIILLMGL FSIYTGLIYN DIFSLSANIF GSSWYPTYDN
     SVLSKEVRLQ LEPRTSVNVS DRMYAGYPYP FGLDPVWQLS GNKIMLTNSI KMKMSVVLGV
     LHMLLGISLG AFNYRNNKDN LSIWCLLLPQ ILFLSCIFLY LVILIFFKWV AYTAETASSA
     PSLLIGLINM IRFSYSDEIP PLYSGQKAVQ SILMVVAVIC VPWMLLSKPL ILYMRHRAIL
     KNRHYVDPDA SVHVVVGGVT NPNMDDSFTG DNNGIMYSDM SPLHRSSSEK RSKVSLISQT
     DSPRSHDVHK FDFGDIMVHQ SIHTIEFCLG CISNTASYLR LWALSLAHAQ LSEVLWSMVM
     RMGLRISGLY GGVVLAFIFA FWAVLTVSIL LCMEGLSAFL HTLRLHWVEF QNKFYSGDGY
     PFVPFTFEHS NSLVDN
//
DBGET integrated database retrieval system