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Database: UniProt
Entry: G4V7J9_SCHMA
LinkDB: G4V7J9_SCHMA
Original site: G4V7J9_SCHMA 
ID   G4V7J9_SCHMA            Unreviewed;       649 AA.
AC   G4V7J9;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   25-APR-2018, entry version 42.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Smp_040970.2 {ECO:0000313|EMBL:CCD75994.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of
RT   the human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE601624; CCD75994.1; -; Genomic_DNA.
DR   RefSeq; XP_018648868.1; XM_018794457.1.
DR   ProteinModelPortal; G4V7J9; -.
DR   EnsemblMetazoa; Smp_040970.1; Smp_040970.1:pep; Smp_040970.
DR   EnsemblMetazoa; Smp_040970.2; Smp_040970.2:pep; Smp_040970.
DR   GeneDB; Smp_040970.2:pep; -.
DR   GeneID; 8343995; -.
DR   CTD; 8343995; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; G4V7J9; -.
DR   OrthoDB; EOG091G01BI; -.
DR   PhylomeDB; G4V7J9; -.
DR   Proteomes; UP000008854; Chromosome 1.
DR   ExpressionAtlas; G4V7J9; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008854};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    180    213       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    233    252       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    328    348       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    354    380       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    421    439       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    581    604       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   649 AA;  73841 MW;  876BFD04DB469585 CRC64;
     MPVHKSVFLV FFQGDQLRTR VKKICDGFHA TLYPCPDSQA DRRNMAIEVM GQIQDLETVL
     TQTRQHRQRI LETAAKNLRT WFIRVRKIKA IYHTLNLFNL DVTTKCMVGE CWCAVNDVDK
     INLALRRGME RSNSTLQPIL NGIVTTENPP TYHRTNKFTY AFQSIIDAYG VARYREVNPA
     LFTVITFPFL FAVMFGDAGH GLLMFLFALW MVVCERKLSA NKSGGEIWNI FFSGRYIILL
     MGLFSIYTGL IYNDIFSLSA NIFGSSWYPT YDNSVLSKEV RLQLEPRTSV NVSDRMYAGY
     PYPFGLDPVW QLSGNKIMLT NSIKMKMSVV LGVLHMLLGI SLGAFNYRNN KDNLSIWCLL
     LPQILFLSCI FLYLVILIFF KWVAYTAETA SSAPSLLIGL INMIRFSYSD EIPPLYSGQK
     AVQSILMVVA VICVPWMLLS KPLILYMRHR AILKNRHYVD PDASVHVVVG GVTNPNMDDS
     FTGDNNGIMY SDMSPLHRSS SEKRSKVSLI SQTDSPRSHD VHKFDFGDIM VHQSIHTIEF
     CLGCISNTAS YLRLWALSLA HAQLSEVLWS MVMRMGLRIS GLYGGVVLAF IFAFWAVLTV
     SILLCMEGLS AFLHTLRLHW VEFQNKFYSG DGYPFVPFTF EHSNSLVDN
//
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