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Database: UniProt
Entry: G4V8C9_SCHMA
LinkDB: G4V8C9_SCHMA
Original site: G4V8C9_SCHMA 
ID   G4V8C9_SCHMA            Unreviewed;      1699 AA.
AC   G4V8C9;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   22-NOV-2017, entry version 38.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Smp_020270 {ECO:0000313|EMBL:CCD75074.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|Proteomes:UP000008854};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of
RT   the human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; HE601624; CCD75074.1; -; Genomic_DNA.
DR   RefSeq; XP_018647949.1; XM_018793436.1.
DR   STRING; 6183.Smp_020270__mRNA; -.
DR   EnsemblMetazoa; Smp_020270.1; Smp_020270.1:pep; Smp_020270.
DR   GeneDB; Smp_020270.1:pep; -.
DR   GeneID; 8353095; -.
DR   CTD; 8353095; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   InParanoid; G4V8C9; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   PhylomeDB; G4V8C9; -.
DR   Proteomes; UP000008854; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008854};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     79     96       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    117    137       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    143    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    206    228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    298    322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    328    353       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    452    474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    494    511       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    523    542       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    587    611       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    623    640       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    660    684       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    809    831       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    851    872       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    884    910       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    930    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1056   1082       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1134   1151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1163   1183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1195   1213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1280   1303       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1445   1479       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      688    711       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1699 AA;  194631 MW;  FCDA6EF44A544E8B CRC64;
     MIPTPGQNPW GTPGSGGNAF LQSNKPLIAD LALAALKERG EVKKKKLCPQ FRTDRSLCLM
     TKKNPLRRVC ICIVDARPFE YFILATILCN CLALAFNHPY PGEDSNAVNQ VLEKVELAFV
     IIFTTESALK IIAYGFVLHQ DAYLRNFWNV LDFSIVLIGY VSTLENMNID VKALRAFRVL
     RPLRLLSGLP SLQVVLNSII TAMVPLLHIA LLVIFVIIVY AIVGLELFQS KLHLTCYRNS
     THKIPEMMPN PRPCTFETSS MGFKCSELGP DYFCADMYGK EGERYTGPEG GIVSFDNFLY
     SMLTVFVCIT MEGWTSTGYY VSDAIGSWWP WIYFVTLILL GSFFVMNLVL GVLSGEFSKE
     KEKIDRTLLF RKERQEKREQ QDYLGYKEWI ELAEELSDSE GDDKESQDIE SVDGGDGLIE
     EEPEMHVEEV VKTHCHSTLR RLRKFRKRTR RAVIAFINSR QCFALVIILV FLNTVVLTTE
     HHNQPEWLDE FQDFANVVFV TLFTMEMVIK MGASGFSDYI SKLFNRFDFF VVIFSILELL
     FVKSGLLNPM GVSVLRCARL LRIFKLTQYW ESLRSLVGKL LKSVRSVASL LLLLSIFILI
     CSLLGMQLFG GRFNFIAHEK PRANFDGILQ AMLTVFQILT GEDWNEVMYH GMRAYENSPW
     YGVVVIYFIF LFICGNCILL NVFLAIAVDN LNEDEDEEDE ANGDAQKKQN DTPELTETVE
     QTAPPPEQPE NELTSVMKIK QYERTDNEDQ TYEEMFAEDE DVEEEGGLNG KDGDDQKDMS
     PQDSRTMPPH SAFFIFADTN KFRIFCHNVV CFSHFGNIVL VCILVSSILL AAEDPLHANS
     PRNRILNMFD YFFTSVFTVE ITLKMISYGF VLHEGAFCRS VFNLLDLIVV CVALVSFVLQ
     NQTISAVKIL RVLRVLRPLR AINRAKGLKH VVQCMIIAIK SIGNIVLVTF LLEFMFAVIG
     VQLFKGKFYS CTDISKHVEE DCKGQFIEYK DMSLEDPILS EREWKNSDFN FDNVPNALLT
     LFAVSTFEGW PSLLYRSIDS NAEDHGPITN YRPVVAFFYI TFIILIPFFM INIFVGFVIV
     TFQKEGEAEY KNCELNKNQR KCIEYALKAR PRRRYIPKGH LQFKIWSVVV SKRFEILIFI
     FIFINTVALM LKYDKQGKLE ARILDSFNYF FTAVFTVEFI LRLSAFSFRH YFSDIWNVID
     FVLVLGSYID IIVTQSDISQ VKFSVNFFRL FRVMRLIKLL SKEESIRQLL WTFIKSIQGQ
     KCSKDSDETE VNGCGSKLAY AYFISFHAIS AFLVINLFVA VIMDNFDYLT RDWSILGPHH
     LDEFITKWAD YDPEAKGRVR HLDVVTMLGK ISPPLGFGSM CPHTRACHKL VRMNMPLNSD
     GTVFFNATLF ALVRRNLKIK IPGAEIGEKE KSLDQLNEEL RIVIKRIWKR TSPKLLDQII
     PPKGSDVVTV GKFYATFLIQ NWFREWQKRK MIQKDTRYIP QIMAGDRAMP HQPTIIGFPR
     RCSSDLTGDE IQRRRGVDKR DTSGGIFGRT LSEWTRRRSS KRPSGRRDIN AQQANGMYDI
     AGNHLKNGMG IWNDMFLNAQ AGKTAHPAVV ALMEKERKDA EARNMANMNH LVDVHNDSSK
     LNYDPESGKL MNLAGNMLGF LNSRNYHSSD STQPKDTKTS NTPSVEDLNT ARKIFVAARR
     ESLLSNKNEV RKNLNVFIL
//
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