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Database: UniProt
Entry: G4VGD7_SCHMA
LinkDB: G4VGD7_SCHMA
Original site: G4VGD7_SCHMA 
ID   G4VGD7_SCHMA            Unreviewed;       715 AA.
AC   G4VGD7;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   22-NOV-2017, entry version 48.
DE   SubName: Full=Putative cyclic-nucleotide-gated cation channel {ECO:0000313|EMBL:CCD78058.1};
GN   ORFNames=Smp_194700 {ECO:0000313|EMBL:CCD78058.1};
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183 {ECO:0000313|EMBL:CCD78058.1, ECO:0000313|Proteomes:UP000008854};
RN   [1] {ECO:0000313|Proteomes:UP000008854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puerto Rican {ECO:0000313|Proteomes:UP000008854};
RX   PubMed=22253936; DOI=10.1371/journal.pntd.0001455;
RA   Protasio A.V., Tsai I.J., Babbage A., Nichol S., Hunt M., Aslett M.A.,
RA   De Silva N., Velarde G.S., Anderson T.J., Clark R.C., Davidson C.,
RA   Dillon G.P., Holroyd N.E., LoVerde P.T., Lloyd C., McQuillan J.,
RA   Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A., Wilson R.A.,
RA   Zerlotini A., Dunne D.W., Berriman M.;
RT   "A systematically improved high quality genome and transcriptome of
RT   the human blood fluke Schistosoma mansoni.";
RL   PLoS Negl. Trop. Dis. 6:E1455-E1455(2012).
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DR   EMBL; HE601626; CCD78058.1; -; Genomic_DNA.
DR   RefSeq; XP_018650675.1; XM_018798825.1.
DR   ProteinModelPortal; G4VGD7; -.
DR   STRING; 6183.Smp_194700__mRNA; -.
DR   EnsemblMetazoa; Smp_194700.1; Smp_194700.1:pep; Smp_194700.
DR   GeneDB; Smp_194700.1:pep; -.
DR   GeneID; 8352031; -.
DR   CTD; 8352031; -.
DR   eggNOG; KOG0500; Eukaryota.
DR   eggNOG; ENOG410YWWI; LUCA.
DR   InParanoid; G4VGD7; -.
DR   OMA; CMYFAIS; -.
DR   OrthoDB; EOG091G03EW; -.
DR   PhylomeDB; G4VGD7; -.
DR   Proteomes; UP000008854; Chromosome 3.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR032406; CLZ_dom.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF16526; CLZ; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008854};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008854};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    101    121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    182    205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    235    259       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    294    312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    349       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      427    529       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      565    596       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   715 AA;  83123 MW;  4041EE9605BE9E04 CRC64;
     MAEIVETPDI AFQNLESRSK SSIMKRLIFC FSKKYKREKQ NDSAVENLII NKDTEAGDKK
     NDTNKQETEG ETKKKLTIRQ RIQNIPSNLK DLVIDSSESG YYYWIGIVTI TVLYNAIVLP
     MRSAFTQFHE LSPITWMVLD YCIDCVYFMD IFVGFRTGYL EEGLLVRDKE KLKQAYLKRR
     QFIIDIITIL PTDLLYLIPI FNHYASWLRF NRLMKIYRSF EFVDRTETRT NRPNLFRISM
     LTTYILVLIH WNACIYFGFS RASGLSSDSF VYPPRSSDDT SDEYKNYTEQ WDRLFSQYVY
     SFYWSTLILT TIGETPKPVR NAEYIFITID FLVGVLIFAT VVGNVGAMIT NMNAARTEFQ
     NKMDGVKRYM EFRKVNKELE LRVIRWFDYL WTNKQSLEED SLNALPDKLK AEIAIHVHFD
     TLQRVSIFKD CDPGLLVELV LKLQLQVFSP GDYICRKGDI GKEMYIVKRG KLSVVSEDGK
     TVFVTLGEGS VFGEISILNI AGNKTGNRRS ANVRSVGYSD LFCLSKDDLW DALTEYPETK
     TILMQRGQDI LRKDNLLDED ILRKAQEQQE SIEQCVQRID NTMNQLTTRL ARLIGEFGAS
     QAKLKRRLTR LEQEYDMNSS CLVQDNNNDN HSPRYRKYSD QLTNDSQLPM NTESEYNRKS
     IQTIRQKQGI QLKINHKQRN TSNSSSTSIY DKRESLSSLG SNITNDTLPF VQDDE
//
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