ID G4WJ13_TRYCR Unreviewed; 346 AA.
AC G4WJ13;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
DE EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
DE Flags: Fragment;
GN Name=GPI {ECO:0000313|EMBL:AEQ53984.1};
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693 {ECO:0000313|EMBL:AEQ53984.1};
RN [1] {ECO:0000313|EMBL:AEQ53984.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ARMA18 cl3 {ECO:0000313|EMBL:AEQ53984.1};
RA Lewis M.D., Llewellyn M.S., Yeo M., Acosta N., Gaunt M.W., Miles M.A.;
RT "Recent, Independent and Anthropogenic Origins of Trypanosoma cruzi
RT Hybrids.";
RL PLoS Negl. Trop. Dis. 5:e1363-e1363(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC ECO:0000256|RuleBase:RU000612};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC ECO:0000256|RuleBase:RU000612}.
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DR EMBL; HQ452718; AEQ53984.1; -; Genomic_DNA.
DR AlphaFoldDB; G4WJ13; -.
DR VEuPathDB; TriTrypDB:BCY84_19402; -.
DR VEuPathDB; TriTrypDB:C3747_50g105; -.
DR VEuPathDB; TriTrypDB:C4B63_41g194; -.
DR VEuPathDB; TriTrypDB:ECC02_002443; -.
DR VEuPathDB; TriTrypDB:Tc_MARK_5695; -.
DR VEuPathDB; TriTrypDB:TcBrA4_0067590; -.
DR VEuPathDB; TriTrypDB:TcCL_NonESM01484; -.
DR VEuPathDB; TriTrypDB:TcCLB.506529.508; -.
DR VEuPathDB; TriTrypDB:TcCLB.510889.221; -.
DR VEuPathDB; TriTrypDB:TCDM_05039; -.
DR VEuPathDB; TriTrypDB:TcG_02388; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_006941; -.
DR UniPathway; UPA00109; UER00181.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR Gene3D; 1.10.1390.10; -; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR023096; G6P_Isomerase_C.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW ECO:0000256|RuleBase:RU000612};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEQ53984.1"
FT NON_TER 346
FT /evidence="ECO:0000313|EMBL:AEQ53984.1"
SQ SEQUENCE 346 AA; 38401 MW; 3F29C5B012E38C2A CRC64;
EVLKLVDLES TLFIIASKTF TTQETITNAL SARSEFLKFL SSRGIPEAGA VAKHFVALST
NAEKVKEFGI DEANMFQFWD WVGGRYSLWS AIGLSIMISI GYDNFVEFLT GAHIMDEHFI
NAPTENNLPI ILALVGIWYN NFFGSETQAI LPYDQYLWRL PAYLQQLDME SNGKGATKNG
RMVSTHTGPI IFGEAGTNGQ HAFYQLIHQG TKLIPCDFIG AIQTQNYIGE HHRILMSNFF
AQTEALMIGK TPEEVKRELE SAGGKSEDEI QLLIPQKTFT GGRPSNSLLV KALTPRALGA
IIAMYEHKVL VQGAIWGINS YDQWGVELGK LLAKSILPQL QPGQKV
//