ID   G4XHZ9_HBV              Unreviewed;       478 AA.
AC   G4XHZ9;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=P {ECO:0000313|EMBL:AEQ33698.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AEQ33698.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AEQ33698.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HBV21 {ECO:0000313|EMBL:AEQ33698.1};
RX   PubMed=22012717; DOI=10.1002/jmv.22246;
RA   Reis L.M., Soares M.A., Franca P.H., Soares E.A., Bonvicino C.R.;
RT   "Clonal analysis of hepatitis B viruses among blood donors from Joinville,
RT   Brazil: evidence of dual infections, intragenotype recombination and
RT   markers of risk for hepatocellular carcinoma.";
RL   J. Med. Virol. 83:2103-2112(2011).
RN   [2] {ECO:0000313|EMBL:AEQ33698.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HBV21 {ECO:0000313|EMBL:AEQ33698.1};
RA   Reis L.M.W., Soares M.A., Franca P.C., Soares E.A.J.M., Bonvicino C.R.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; JF815625; AEQ33698.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          165..408
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEQ33698.1"
FT   NON_TER         478
FT                   /evidence="ECO:0000313|EMBL:AEQ33698.1"
SQ   SEQUENCE   478 AA;  53184 MW;  A5F9DAAE90DA5520 CRC64;
     GAESFHQQSS GILSRPPVGS SLQSKHRKSR LGLQSQQGHL ARRQQGRSWS IRAGFHPTAR
     RPFGVEPSGS GHTTNFASKS ASCLHQSTVR KAAYPAVSTF EKHSSSGHAV ELHNLPPNSA
     RSQSERPVFP CWWLQFRNSK PCSDYCLSLI VNLLEDWGPC AEHGEHHIRI PRTPSRVTGG
     VFLVDKNPHN TAESRLVVDF SQFSRGNHRV SWPKFAVPNL QSLTNLLSSN LSWLSLDVSA
     AFYHLPLHPA AMPHLLVGSS GLSGYVARLS SNSRIINHQH GTMPNLHDSC SRNLYVSLLL
     LYQTFGRKLH LYSHPIILGF RKIPMGVGLS PFLLAQFTSA ICSVVRRAFP HCLAFSYMDD
     VVLGAKSVQH LESLFTAVTN FLLSLGIHLN PNKTKRWGYS LNFMGYVIGC YGSLPQEHIV
     QKIKECFRKL PINRPIDWKV CQRIVGLLGF AAPFTQCGYP ALMPLYACIQ SKQAFTFS
//