ID G4XJR8_CHICK Unreviewed; 818 AA.
AC G4XJR8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Toll-like receptor 1 type 1 {ECO:0000313|EMBL:AEP40329.1};
GN Name=TLR1LA {ECO:0000313|EMBL:AEP40329.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AEP40329.1};
RN [1] {ECO:0000313|EMBL:AEP40329.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21844258;
RA Ruan W.K., Zheng S.J.;
RT "Polymorphisms of chicken toll-like receptor 1 type 1 and type 2 in
RT different breeds.";
RL Poult. Sci. 90:1941-1947(2011).
RN [2] {ECO:0000313|EMBL:AEP40329.1}
RP NUCLEOTIDE SEQUENCE.
RA Ruan W., Wu Y., Zheng S.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; JF823975; AEP40329.1; -; mRNA.
DR AlphaFoldDB; G4XJR8; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..818
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003470963"
FT TRANSMEM 592..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 646..789
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 818 AA; 94599 MW; 28B7E2C5A1B1842A CRC64;
MGSLTSIYVF ACVFLSILWN NIQPTVENKI TANYSGHLLT EVPKNIPVHT HILDLSHNSI
SEITNFRFTS LSDLQVLNLS HNLITELDFS AFMFNQDLEY LDLSHNNIWT AYCQLLARLR
HLDLSFNKFT VLPICQEFGI MFHLEYLGLS AMMIRRSDFR YVAHLQLDTV FLTLEDFSLY
EPLSLTALNT RSLHIVFATN QNFNFSLLYD GMSTSEKLKI VNLRYTLSHK DFPSPSLELQ
KKIKTTDLTL DTVDLEWTVI LQIFLLVWDS SVEHLTVRNL IFRGPVVELT EYKHVPLLRS
LEQLLSLGSS MKALTLERVR NKLYYFNQEI LYRQFSEMNI DSLTIHDACM PHMLCPKKRS
SFQYINFSRN ALTDELFQNC DTLANLKILI LHRNKFESLS KVSFMTSRMK SLRYLDMSSN
LLRNSRAEGR CQWADSLAEL DLSSNQLTEA VFECLPANIN KVDLQNNQIA NVPKGITELH
SLQELNLASN RLADLPGCRA FTGLEILNIE RNLILTPSAD FFETCPSVKE LQAGQNPFKC
SCELQDFLRL ERQSGGKLSS WPEAYVCKYP EDLSGTQLKD FHLTELACNT TLLLVTALLL
TLVLVAVVAF LCIYLDVPWY VRMLWQWTQT KRRAWHDCPE ERETALQFHA FISYSERDSL
WVKNELIPNL EKGEGCIQLC QHERNFIPGK SIVENIINCI EKSYKSIFVL SPNFVQSEWC
HYELYFAHHR LFSENSNSLI LILLEPIPSY VIPARYHKLK ALMAKRTYLE WPKERSKHAL
FWANLRAAVN IKLPTSFETD EEQSDVTSTS SITQRLIK
//
