ID G4XJS8_CHICK Unreviewed; 529 AA.
AC G4XJS8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Toll-like receptor 1 type 2 {ECO:0000313|EMBL:AEP40339.1};
DE Flags: Fragment;
GN Name=TLR1LB {ECO:0000313|EMBL:AEP40339.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AEP40339.1};
RN [1] {ECO:0000313|EMBL:AEP40339.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21844258;
RA Ruan W.K., Zheng S.J.;
RT "Polymorphisms of chicken toll-like receptor 1 type 1 and type 2 in
RT different breeds.";
RL Poult. Sci. 90:1941-1947(2011).
RN [2] {ECO:0000313|EMBL:AEP40339.1}
RP NUCLEOTIDE SEQUENCE.
RA Ruan W., Wu Y., Zheng S.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; JF823985; AEP40339.1; -; mRNA.
DR AlphaFoldDB; G4XJS8; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AEP40339.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 317..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 371..514
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEP40339.1"
SQ SEQUENCE 529 AA; 60791 MW; CA04A21787A94B45 CRC64;
LLQVVWHSSI EYFNINNLTQ LGNVVSTRFD YSNTSMKAFA VNKVLITDLY FSQDDVYNIF
ANMNIAALTI AESELIHMLC PSSDSPLRYI NFSKNDLTDL LFQNCDKLIQ LETFILHRNK
FESLSKVSLM TSRMKSLRYL DMSSNLLRNS RAEGRCQWAD SLAELDLSSN QLTEAVFECL
PANINKVDLQ NNQIASVPKG ITELHSLQEL NLASNRLADL PGCRAFTGLE ILNIERNLIL
TPSADFFETC PSVKELQAGQ NPFKCSCELQ DFLRLERQSG GKLSGWPEAY VCKYPEDLSG
TQLKDFHLTE LACNTTLLLV TALLLTLVLV AVVAFLCIYL DVPWYVRMLW QWTQTKRRAW
HDCPEERETA LQFHAFISYS ERDSLWVKNE LIPNLEKGEG CIQLCQHERN FIPGKSIVEN
IINCIEKSYK SIFVLSPNFV QSEWCHYELY FAHHKLFSEN SNSLILILLE PIPPYVIPAR
YHKLKALMAK RTYLEWPKER SKHALFWANL RAAISINLSV ADEQNRTEV
//
