ID G4XMX1_SOLLC Unreviewed; 257 AA.
AC G4XMX1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Calcineurin B-like protein {ECO:0000256|RuleBase:RU369080};
GN Name=CBL10 {ECO:0000313|EMBL:AEP33594.1};
GN Synonyms=100820706 {ECO:0000313|EnsemblPlants:Solyc08g065330.3.1},
GN SlCBL10 {ECO:0000313|EMBL:BAL04563.1};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EMBL:AEP33594.1};
RN [1] {ECO:0000313|EMBL:BAL04563.1}
RP NUCLEOTIDE SEQUENCE.
RA Yuasa T., Iwaya-Inoue M.;
RT "Tomato calcineurin B-like molecules.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:Solyc08g065330.3.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc08g065330.3.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [3] {ECO:0000313|EMBL:AEP33594.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23903322; DOI=10.1105/tpc.113.113530;
RA de la Torre F., Gutierrez-Beltran E., Pareja-Jaime Y., Chakravarthy S.,
RA Martin G.B., Del Pozo O.;
RT "The tomato calcium sensor cbl10 and its interacting protein kinase cipk6
RT define a signaling pathway in plant immunity.";
RL Plant Cell 25:2748-2764(2013).
RN [4] {ECO:0000313|EnsemblPlants:Solyc08g065330.3.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc08g065330.3.1};
RG EnsemblPlants;
RL Submitted (JAN-2019) to UniProtKB.
CC -!- FUNCTION: Acts as a calcium sensor. CBL proteins interact with CIPK
CC serine-threonine protein kinases. Binding of a CBL protein to the
CC regulatory NAF domain of a CIPK protein lead to the activation of the
CC kinase in a calcium-dependent manner. {ECO:0000256|RuleBase:RU369080}.
CC -!- SUBUNIT: Homodimer. Interacts with CIPK.
CC {ECO:0000256|RuleBase:RU369080}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU369080}.
CC -!- SIMILARITY: Belongs to the calcineurin regulatory subunit family.
CC {ECO:0000256|ARBA:ARBA00023774, ECO:0000256|RuleBase:RU369080}.
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DR EMBL; JF831199; AEP33594.1; -; mRNA.
DR EMBL; AB675689; BAL04563.1; -; mRNA.
DR RefSeq; NP_001239045.1; NM_001252116.2.
DR AlphaFoldDB; G4XMX1; -.
DR SMR; G4XMX1; -.
DR STRING; 4081.G4XMX1; -.
DR PaxDb; 4081-Solyc08g065330-2-1; -.
DR EnsemblPlants; Solyc08g065330.3.1; Solyc08g065330.3.1; Solyc08g065330.3.
DR GeneID; 100820706; -.
DR Gramene; Solyc08g065330.3.1; Solyc08g065330.3.1; Solyc08g065330.3.
DR KEGG; sly:100820706; -.
DR eggNOG; KOG0034; Eukaryota.
DR HOGENOM; CLU_061288_21_0_1; -.
DR InParanoid; G4XMX1; -.
DR OMA; AVAKKWN; -.
DR OrthoDB; 90710at2759; -.
DR Proteomes; UP000004994; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019900; F:kinase binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:UniProtKB-UniRule.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR045198; CNBL1-10.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR23056; CALCINEURIN B; 1.
DR PANTHER; PTHR23056:SF26; CALCINEURIN B-LIKE PROTEIN 10; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU369080};
KW Membrane {ECO:0000256|RuleBase:RU369080};
KW Metal-binding {ECO:0000256|RuleBase:RU369080};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369080}.
FT DOMAIN 107..142
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 144..179
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 188..223
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 257 AA; 29877 MW; 62F91B514A95CDC9 CRC64;
MDSTRNSLSW SSLTISEKIC ASFFPIIALI EACMYAVSGC FECHYPPNKK FSYEYTDLAR
LAGESRFNVN EVEALYELFK KLSCSIIDDG LIHKEELQLA LFQTPHGENL FLDRVFDLFD
EKQNGVIEFE EFIHALNIFH PYAPIDDKID FAFRLYDLRQ TGYIEREEVK QMVIAILMES
EMRLSDELVE EIIDKTFADA DADGDGKIDK KDWKEFAIRY PSLLKNMTLP YLKDITTSFP
SFVFHTQVED IEKIHLL
//
