ID G4ZM53_PHYSP Unreviewed; 1817 AA.
AC G4ZM53;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=phospholipase D {ECO:0000256|ARBA:ARBA00012027};
DE EC=3.1.4.4 {ECO:0000256|ARBA:ARBA00012027};
GN ORFNames=PHYSODRAFT_286421 {ECO:0000313|EMBL:EGZ16020.1};
OS Phytophthora sojae (strain P6497) (Soybean stem and root rot agent)
OS (Phytophthora megasperma f. sp. glycines).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1094619 {ECO:0000313|EMBL:EGZ16020.1, ECO:0000313|Proteomes:UP000002640};
RN [1] {ECO:0000313|EMBL:EGZ16020.1, ECO:0000313|Proteomes:UP000002640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P6497 {ECO:0000313|EMBL:EGZ16020.1,
RC ECO:0000313|Proteomes:UP000002640};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000798};
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DR EMBL; JH159155; EGZ16020.1; -; Genomic_DNA.
DR RefSeq; XP_009529769.1; XM_009531474.1.
DR STRING; 1094619.G4ZM53; -.
DR EnsemblProtists; EGZ16020; EGZ16020; PHYSODRAFT_286421.
DR GeneID; 20640357; -.
DR KEGG; psoj:PHYSODRAFT_286421; -.
DR InParanoid; G4ZM53; -.
DR OMA; YTKRSLM; -.
DR Proteomes; UP000002640; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd09138; PLDc_vPLD1_2_yPLD_like_1; 1.
DR CDD; cd09141; PLDc_vPLD1_2_yPLD_like_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR015679; PLipase_D_fam.
DR PANTHER; PTHR18896:SF76; PHOSPHOLIPASE; 1.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR Pfam; PF00614; PLDc; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 260..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 858..885
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 1256..1283
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1539..1655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1665..1684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1817 AA; 203737 MW; 3BC86D3F54B896C0 CRC64;
MPGPDDDAVE QTAAVRTNSS GYGLKAAPSF STSGLGSVAS VNSYRSSSVD GQEVDVDDCN
EECADSDILE SPNDGEMTIM NDDDADLSEE EEEVMEHSID FSVNRATVTR AGVIPCCVFV
ARVRWGTTDW EIYFGQKQIL RLHFQLHLYC LLHRHKFMRG VHLPWTIWRE KRAEKRVADV
YVVQDYIRTL LKDRDLRNSE PLLSFLEVSP SRAMLRLGPS LKEGYVHMRI NGPFQLPLYT
CFNRTIEALY RHLYRAWMRI AFVSAIVGFI FPVCLVIVTS LPTFFSPQKE LVNSDSGTKE
VSTKLNTAGV FLGLAVLAGI IFFAGFVYKF FQHRLGVIRR WVVLKPSCFA AYRNRNDREP
SEVFLFDKTF TARKGSYRQG VSWMPSGLVV GSKAGDIEID TGHYYTRLTA FIALMGVCYG
IMRLSNSIYD FETLSLDKSL GVPITNASGY ENWTETNDIE YCGYYFTVPH GVTVYVESDE
DNAVVSQLQM PSANSMTANL GYFWQSDSMG NSLNVITNAV GAGTMMSVVK PIDAKNDRFF
ESGTNYSLPS VGNLTLEGVD TDIDVQSYSN VDSLCAISVR ISPVTWRSYI FYIMFLFAGG
IIAPVVGFLA NYFVTYLGVW HPHVRRDHWF RCVRRLQKLK RHETSTRFNS FAPQHVSTLA
DDDSAAIVAK AKAARLPPVA VGNTSGSAIN QVVDSVVKLE AEAVARLGSG NLTSASRVDS
STQSEESFEA PPPPPSAVSW HVDAEDTYEA MYKAISNAKY EILIAGWWVC PDLFLLRPGR
KLPPREPDED PNGQQVNKTM LRQLLMKKAE AGVKIYVLIY REVKLALTLN SAYTKRSLMV
HPNIRVLRDP IFQIQSLGFW SHHEKIVCID QSLAFVGGLD LCFGRYDHHG HPISDPSDDP
VWRGKDYSNP IIKDFVRVNK PFEDLIDRGS QPRMPWHDVH CSISGPPVQD VAYHFIQRWN
FVCSKNDYQL RTGWCICFRS RRFKFLPKCL VPMDFNGWTL QYPSSDPEAM LERDGSTRTT
IPLVREDSLS MVEPFQVVQS LNPMYPCAAT GPQWPPTSSL NPLNPIRPPI TSASGTAGQL
DDGEVLRAQR GESILQVFHP SASICNIQVC RSVSMWSAGV PTEASIQAAY MDVIANSKHY
LYIENQFFIS GMDGNGIVRN RILQALVDRI ERAVQRDEKF RVYVVMPLLP AFEGNVRSHE
LTNLHAVMHW QFATICRGRY SLFEALKGVT NHPEQYVAFF GLRKYGIMPN GCVSTEQIYI
HSKLMIADDR CAIIGSANIN DRSMNGDRDS EIALVIEDMQ YEDGVMNEKP YRRGVAASKL
RMQLFREHLG LTDDDLSIVD ATSDRTWQAI KATASSNTKI FETVFDCAPS NRMRAFVNFQ
SIEVTQIFEN QRMNVLKVPG RAHVWDAQNL KDGDYAPWTD VNGVPIAADR VDLRDFEVDN
FRDRKKKLFS MDHDGWCYAR NFSIFQEVRT MKTDYKKREK LQHLVADRLM AQVRRRRWVK
KGLLPPRPDP RDSSFSIASD DEEHGRFYSL WRRLQQGDFS RSNSVSTPTN FSHLDTGGSI
ANSVSVGGTH QGRRLHNSSS LPLDGPIMMS NTTPSRPAVL GDNPSYPNSP SVASFQTPQS
PSMNALQGGP RSVRGGRTQS LLGTGGGVRT RANTRSARGS FIGMFSVTSG NRNDTDDDSS
DAGSDYGGGH GIRASLKRWY SAVDVLDFGR RSKFNAEYFD GDDHLNGDDP LLEEGQGSYH
AATREGLLME EGAEGSDAED ADCQISHVQT AATVRKEDET RARGQLSEIR GHLVEFPLDF
LVEEILKPSV LPADIHI
//
