ID G5AKJ1_HETGA Unreviewed; 415 AA.
AC G5AKJ1;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Mannose-1-phosphate guanyltransferase alpha {ECO:0000256|ARBA:ARBA00040222};
DE AltName: Full=GDP-mannose pyrophosphorylase A {ECO:0000256|ARBA:ARBA00042915};
DE AltName: Full=GTP-mannose-1-phosphate guanylyltransferase alpha {ECO:0000256|ARBA:ARBA00041992};
GN ORFNames=GW7_07271 {ECO:0000313|EMBL:EHA97551.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA97551.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA97551.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- FUNCTION: May serve as a regulatory subunit and allow allosteric
CC feedback inhibition of GMPPB by GDP-mannose.
CC {ECO:0000256|ARBA:ARBA00037787}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
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DR EMBL; JH165659; EHA97551.1; -; Genomic_DNA.
DR STRING; 10181.G5AKJ1; -.
DR eggNOG; KOG1460; Eukaryota.
DR InParanoid; G5AKJ1; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd06428; M1P_guanylylT_A_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572:SF104; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transferase {ECO:0000313|EMBL:EHA97551.1}.
FT DOMAIN 3..194
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 415 AA; 45733 MW; 402B3FF646BE4527 CRC64;
MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMIQHH IEACVQVPGM QEILLIGFYQ
PDESLMQFLE AAQQEFNLPV RYLQEFAPLG TGGGLYHFRD QILAGGPEAF FVLNADVCSD
FPLSAMLDVH RRHCHPFLLL GTRANRTQSL NYGCIVENPQ THEVLHYVEK PSTFISDIIN
CGIYLFSPEA LTPLRDVFQR NXEDSPSSWP GAGTIRLEQD VFSNLAGKGQ IYVHITEGIW
SQIKSAGSAL YASRLYLGQY QITHPERLAK HSPGGPRIRG NVYIHPTAKV APSAVLGPNV
SIGKGVTVGE GVRLRESIVL HGATLQEHTC VLHSIVGWGS TVGRWARVEG TPNDPNPNDP
RARMDSESLF KDGKLLPAIT ILGCRVRIPA EVLILNSIVL PHKELSRSFT NQIIL
//
