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Database: UniProt
Entry: G5ALH6_HETGA
LinkDB: G5ALH6_HETGA
Original site: G5ALH6_HETGA 
ID   G5ALH6_HETGA            Unreviewed;       602 AA.
AC   G5ALH6;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   25-OCT-2017, entry version 35.
DE   SubName: Full=Transient receptor potential cation channel subfamily V member 6 {ECO:0000313|EMBL:EHA97886.1};
GN   ORFNames=GW7_12777 {ECO:0000313|EMBL:EHA97886.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA97886.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHA97886.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
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DR   EMBL; JH165794; EHA97886.1; -; Genomic_DNA.
DR   ProteinModelPortal; G5ALH6; -.
DR   InParanoid; G5ALH6; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 2.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR024862; TRPV.
DR   InterPro; IPR008344; TRPV5/TRPV6.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   PRINTS; PR01765; ECACCHANNEL.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EHA97886.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    327    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    419    444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    450    468       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    489    510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    552    574       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       44    261       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT       78    105       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      116    148       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      162    194       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   602 AA;  68309 MW;  F6745D840E0A4542 CRC64;
     MGLSLPGEKG LILCLWNKFC GLFHRQDSWA QSRDELNLLQ QKRIWESPLL LAAKENDVQA
     LSKLLKYEAC DVHQRGAMGE TALHIAALYD NLEVAMVLME AAPELVFEPM TSELYEGQTA
     LHIAVMNQNM NLVHALLIHG ASVSARATGV AFQRSSNSLI YYGEHPLSFA ACVGSEEIVR
     LLIEHGADIR AQDSLGNTVL HILILQPNKT FACQMYNLLL SYDRRDHLQC LELMPNHQGL
     TPFKLAGVEG NTVLFHHLMQ KRKRIQWTYG PLTSTLYDLT EIDSAGDEQS LLELIVTTKK
     REARQILDQT PVKELVSLKW KRYGRPYFCM LGAVYLLYII CFTVCCVYRP LKPRTTNHTS
     PRDNTLLQQK LLQEAYVTPE DNLRLVGELV SVVGAMIILL VEIPDIFRLG VIHFFGHTIL
     GGPFHVIIVT YAFMVLVTMV MRLTNADGEV VPMSFALVLG WCNVMYFARG FQMLGPFTIM
     IQKMIFGDLM RFCWLMAVVI LGFASAFYII FQTEDPDELG HFYNYPMALF STFELFLTII
     DGPANYDVDL PFMYSITYAA FAIIAALLML NLLIAMMGDT HWRVAHERDE LWRAQVSPWQ
     LG
//
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