ID G5AME7_HETGA Unreviewed; 475 AA.
AC G5AME7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Bone morphogenetic protein 3 {ECO:0000256|ARBA:ARBA00013361, ECO:0000256|PIRNR:PIRNR037403};
GN ORFNames=GW7_06368 {ECO:0000313|EMBL:EHA98207.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHA98207.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHA98207.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037403}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037403}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR037403,
CC ECO:0000256|RuleBase:RU000354}.
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DR EMBL; JH165995; EHA98207.1; -; Genomic_DNA.
DR RefSeq; XP_004848052.1; XM_004847995.2.
DR AlphaFoldDB; G5AME7; -.
DR STRING; 10181.G5AME7; -.
DR Ensembl; ENSHGLT00000010712; ENSHGLP00000010593; ENSHGLG00000007595.
DR Ensembl; ENSHGLT00100005641; ENSHGLP00100005559; ENSHGLG00100004212.
DR GeneID; 101698732; -.
DR KEGG; hgl:101698732; -.
DR CTD; 651; -.
DR eggNOG; KOG3900; Eukaryota.
DR InParanoid; G5AME7; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0070700; F:BMP receptor binding; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:InterPro.
DR CDD; cd19393; TGF_beta_BMP3; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR017197; BMP3/BMP3B.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF144; BONE MORPHOGENETIC PROTEIN 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037403; BMP3/GDF10; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|PIRNR:PIRNR037403};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR037403-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR037403};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037403};
KW Signal {ECO:0000256|PIRNR:PIRNR037403}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|PIRNR:PIRNR037403"
FT CHAIN 23..475
FT /note="Bone morphogenetic protein 3"
FT /evidence="ECO:0000256|PIRNR:PIRNR037403"
FT /id="PRO_5005153439"
FT DOMAIN 363..475
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 68..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 373..440
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 402..472
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 406..474
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 439
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
SQ SEQUENCE 475 AA; 52886 MW; A94CB386683EF1E6 CRC64;
MAGARGLLGL WLGCFCVSLA RGETPERRLP ELHGAAPAER PAGGGASPEL PPHDQVSEHM
LRLYDRYRGG GGVSAPRTPG SRERGSRPRR PQHARKGNTV RSFRAGAAGT LEGKGLHIFN
MTSLTKSENI LSATLYFNIG ELVNISLSCP VSQGCAHHVQ GKHIQLDLSA WILNSTPNQS
QLLGHLSVDV ARPHGDVASW LSKDITQLLR KAKENDDFLI GFNITSRAHQ LPKRMLPFLE
PYILVYANDA AISEPESVVS SFQAHRNFPT GAVPKLDSHI RAALSIERRK KRSTGVLLPL
QNNELPGAEY QYKEDGVWEE RKPYKSLQTQ PTEKSKNKKK QRKGPHQKSQ TLQFDEQTLK
KARRKQWIEP RNCARRYLKV DFADIGWSEW IISPKSFDAY YCSGACQFPM PKSLKPSNHA
TIQSIVRAVG VIPGIPEPCC VPEKMSSLSI LFFDENKNVV LKVYPNMTVE SCACR
//
