ID G5AU70_HETGA Unreviewed; 996 AA.
AC G5AU70;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Putative global transcription activator SNF2L1 {ECO:0000313|EMBL:EHB00581.1};
DE Flags: Fragment;
GN ORFNames=GW7_03331 {ECO:0000313|EMBL:EHB00581.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB00581.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB00581.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
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DR EMBL; JH166953; EHB00581.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AU70; -.
DR STRING; 10181.G5AU70; -.
DR eggNOG; KOG0385; Eukaryota.
DR InParanoid; G5AU70; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR CDD; cd00167; SANT; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; ISW-1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 137..302
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 432..595
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 797..849
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHB00581.1"
SQ SEQUENCE 996 AA; 116996 MW; 899425A0A7367FF2 CRC64;
KNISPFQLKL ATKASKSEKE MDPEYEEKMK ADRAKRFEFL LKQTELFAHF IQPSAQKSPT
FPLSMKLGRP RIKKDEKQSL ISAGDYRHRR TEQEEDEELL LESRKTSSVC VRFEVSPSYV
KGGALRDYQI RGLNWLISLY ENGVNGILAD EMGLGKTLQT IALLGYLKHY RNIPGPHMVL
VPKSTLHNWM NEFKRWVPSL RVICFVGDKD ARAAFICDEM IPGEWDVCVT SYEMVIKEKS
VFKKFHWRYV VIDEAHRIKN EKSKLSEIVR EFKSTNRLLL TGTPLQNNLH ELWALLNFLL
PDVFNSSDDF DSWFDTKNCF GDQKLVERLH AVLKPFLLRR IKTDVERSLP PKKEIKIYLG
LSKMQREWYT KILMKDIDVL NSAGKMDKMR LLNILMQLRK CCNHPYLFDG AEPGPPYTTD
EHIVSNSGKM VVLDKLLSRL KEQGSRVLIF SQMTRLLDIL EDYCMWRGYE YCRLDGQTPH
EEREDKFLEV ELLGQREAIE AFNVPNSSKF IFMLSTRAGG LGINLASADV VILYDSDWNP
QVDLQAMDRA HRIGQKKPVR VFRLITDDTV EERIVERAEI KLRLDSIVIQ QGRLIDQQSN
KLAKEEMLQM IRHGATHVFA SKETELTDED ITTILERGEK KTAEMNERLH KMGESSLRNF
RMDIEQSLYK FEGEDYREKQ KLGMVEWIEP PKRERKANYA VDAYFREALR VSEPKIPKAP
RPPKQPNVQD FQFFPPRLFE LLEKEILYYR KTIGYKVPRN PEIPNPALVQ REEQKKIDGA
EPLTLEETEE KEKLLTQGFT NWTKRDFNQF IKANEKYGRD DIDNIAREVE GKSPEEVMEY
SAVFWERCSE LQDIEKIMAQ IERGEARIQR RISIKKALDA KIARYKAPFH QLRIQYGTSK
GKNYTEEEDR FLICMLHKMG FDRENVYEEL RQCVRNAPQF RFDWFIKSRT AMEFQRRCNT
LISLIEKENM EIEERERAEK KKRATKTPMV KFSAFS
//