ID G5AWP8_HETGA Unreviewed; 1171 AA.
AC G5AWP8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Putative G-protein coupled receptor 133 {ECO:0000313|EMBL:EHB01506.1};
GN ORFNames=GW7_03171 {ECO:0000313|EMBL:EHB01506.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB01506.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB01506.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR EMBL; JH167272; EHB01506.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AWP8; -.
DR STRING; 10181.G5AWP8; -.
DR eggNOG; KOG4193; Eukaryota.
DR InParanoid; G5AWP8; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF216; ADHESION G-PROTEIN COUPLED RECEPTOR D1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EHB01506.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 866..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 934..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1010..1035
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1056..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1083..1106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 863..1107
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1149..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1171 AA; 125375 MW; 0EB01A52EFB2AC22 CRC64;
MSVAGQWMPS CFPDANGPVS GILLSGFAVL ASASHYWPLE DVDGIQELQD MTGALRAYNL
TGSPSHSPTF VPTSDSAYSN LSATVGEHAS AVSCVVWLPV RGGGQELCPG KGQGHHPGLH
SFPVGCTLPG PGGWLGTAAL SRAGGLRPAV KAPLEPGYLM EAKINKSIYL KEEKGETLLF
YKSTSCISSP ERCSVQGLTF SFFWKTQGEH ARPAPSTYGG QVLSDGFKVC FSGSRGSVQL
CTRDDFMIWQ ATFSPLGPYW THILFTWKSK EGLKVYVNGT LSTSDPSGKV SHDYGEPNAN
LVIGSEQDQT KCYEDGAFDE FIFWERALTP AEVRMYFSAA VGKHGLLSST PPSFVTRTAS
TMAPVDAYHP IITNLTEERQ SFPRARTALN YLQNVTLSLP NKPLSEETAL NLTETFLWAV
GQVLLPPSWT MALEDKALVP DLLDTIDTVM AHVSFNLQGG RSQVTLAGSS PVADFSLARL
TPGTLSAAHY RFPAHGDSYI KIPGEALRGQ AWTTIVGLLY HSVHQYVGNI PLASTTIPML
ASCRDGLLST ASPLISLEVR PPPALSRNLS GSPLVTVQLR HSLGLYTCAL YQEPCPFSIL
LSPRASWAPG WVGSPHCALL HGAPACSTSL GLLSSPALPV PCAFALAHSS RFEQRTQSSE
GEALCRLLAG SRARYGAPLG APFPRQASCG CTSEDPCAPV TGMLDWCPAR AEWGAEDEGQ
TGSAVSPREW AVDGTAACWE DVLCQAGEAR ISSEQALRLG NDLAWFSSPE NDSSPAAPSA
ADLGLYSQTG KQHIDATNGS NHVFLYCAFL DFSSGQGVWS SRGCARVEGN LTYSVCRCTH
LTNFAILMQV VPLELPRGHQ VALSSISYVG CTLSVLCLAA TLVTFAVLSS VSTIRNQRYH
IHANLSCAVL VAQVLLLVSF HAEPGTVPCQ VLATLLHYFF LSTFAWMLVE GLHLYSLVIK
VFGSEGSKHL YYYGIGWGLP LVICVVSISF AMDSYGTSDN CWLSLGTGAI WAFVGPALLV
IVVNVGILIV VTRVISQISA DSCKIHGDPS TFKLTAKAVA VLLPILGTSW AFGVLAVNGQ
ALVFQYMFAV LNSLQGGFIF LFHCLLNSEV RAAFKHKTKV WSLSSSSARN VARKPLSSDT
MNGTHLGSAS TRLGPWDKSS HSAQRVDLSS V
//
