ID G5AXT9_HETGA Unreviewed; 826 AA.
AC G5AXT9;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Lysine-specific histone demethylase 1B {ECO:0000313|EMBL:EHB01850.1};
GN ORFNames=GW7_06946 {ECO:0000313|EMBL:EHB01850.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB01850.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB01850.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH167418; EHB01850.1; -; Genomic_DNA.
DR AlphaFoldDB; G5AXT9; -.
DR STRING; 10181.G5AXT9; -.
DR eggNOG; KOG0029; Eukaryota.
DR InParanoid; G5AXT9; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0140682; F:FAD-dependent H3K4me/H3K4me3 demethylase activity; IEA:UniProt.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.100; -; 1.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007526; SWIRM.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR011124; Znf_CW.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR PANTHER; PTHR10742:SF413; LYSINE-SPECIFIC HISTONE DEMETHYLASE 1B; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR Pfam; PF04433; SWIRM; 1.
DR Pfam; PF07496; zf-CW; 1.
DR PRINTS; PR00419; ADXRDTASE.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50934; SWIRM; 1.
DR PROSITE; PS51050; ZF_CW; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:EHB01850.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transferase {ECO:0000313|EMBL:EHB01850.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00454}.
FT DOMAIN 133..192
FT /note="CW-type"
FT /evidence="ECO:0000259|PROSITE:PS51050"
FT DOMAIN 280..378
FT /note="SWIRM"
FT /evidence="ECO:0000259|PROSITE:PS50934"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 92683 MW; 5B36691E52FE1C1C CRC64;
MAAPRGRSKK RTAFDLTPDS LPLRSSGRQA KKKVTETIEE DEDGVSEKKY RKCEKAGCTA
ACPVCFASAS ERCAKNGYTS RWYHLSCGEH FCNECFDHYY RSHKDGYDKY TTWKKIWTSN
GKTEPSPKAF MADQQLPYWV QCTKPECRKW RQLTKEIQLT PQIAKTYRCG MKPNTMKPES
SDHCSLPEDL RVSEVSNHWW YSMLILPPLL KDSVAAPLLS AYYPDCVGMS PSCTSTNRAA
ASATTATTGD ASPGRLEPSK VAPSVLVPGM NRYFQPFYQP NECGKALCVR PDVMELDELY
EFPEYSRDPT MYLALRNLIL ALWYTNCKEA LTPQKCIPHI IVRGLVRIRC VQEVERILYF
MTRKGLINTG VLTVGADHYL LPKDYHNVVI IVGAGPAGLA AARQLHNFGI KVTVLEAKDR
IGGRVWDDKS FKGVTVGRGP QIVNGCVNNP VALMCEQLGI SMHKFGERCD LIQEGGRITD
PTIDKRMDFH FNALLDVVSE WRKDKTQLQD VPLGEKIEEI YKAFIKESGI QFSELEGQVL
QFHLSNLEYA CGSNLHQVSA RSWDHNEFFA QFAGDHTLLT PGYSVIIEKL AEGLDIRLQS
PVQSIDYTGD EVRVTTTDGM GYSSQKVLVA VPLAILQKGV IQFNPPLSEK KMKAINSLGA
GIIEKIALQF PYRFWDSKVQ GADFFGHVPP SASQRGLFAV YYDMDPQKQQ SVLMSVIAGE
AVASVRTLDD KQVLQQCMAT LRELFKEQEV PDPSKYFVTR WSTEPWIQMA YSFVKTFGSG
EAYDIIAEEI QGTVFFAGEA TNRHFPQTVT GAYLSGVREA SKIAAF
//