ID G5B132_HETGA Unreviewed; 543 AA.
AC G5B132;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=TNF receptor-associated factor 6 {ECO:0000256|ARBA:ARBA00017410};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE AltName: Full=E3 ubiquitin-protein ligase TRAF6 {ECO:0000256|ARBA:ARBA00030810};
DE AltName: Full=RING-type E3 ubiquitin transferase TRAF6 {ECO:0000256|ARBA:ARBA00031646};
GN Name=TRAF6 {ECO:0000313|EMBL:JAO01799.1};
GN ORFNames=GW7_01379 {ECO:0000313|EMBL:EHB02993.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB02993.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB02993.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
RN [2] {ECO:0000313|EMBL:JAO01799.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAO01799.1};
RA Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA Platzer M., Szafranski K.;
RT "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Lipid droplet
CC {ECO:0000256|ARBA:ARBA00004502}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC subfamily. {ECO:0000256|ARBA:ARBA00006608}.
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DR EMBL; JH167916; EHB02993.1; -; Genomic_DNA.
DR EMBL; GEBF01001834; JAO01799.1; -; Transcribed_RNA.
DR RefSeq; XP_004852082.1; XM_004852025.1.
DR AlphaFoldDB; G5B132; -.
DR STRING; 10181.G5B132; -.
DR Ensembl; ENSHGLT00100075836; ENSHGLP00100043180; ENSHGLG00100005898.
DR GeneID; 101697126; -.
DR KEGG; hgl:101697126; -.
DR CTD; 7189; -.
DR eggNOG; KOG0297; Eukaryota.
DR InParanoid; G5B132; -.
DR OrthoDB; 2913784at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000010513; Expressed in heart and 10 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:UniProt.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR CDD; cd03776; MATH_TRAF6; 1.
DR CDD; cd16643; mRING-HC-C3HC3D_TRAF6; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR037309; TRAF6_MATH.
DR InterPro; IPR027139; TRAF6_RING-HC.
DR InterPro; IPR041310; TRAF6_Z2.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF94; TNF RECEPTOR-ASSOCIATED FACTOR 6; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF18048; TRAF6_Z2; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 3.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00207}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000313|EMBL:EHB02993.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00207};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 72..111
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 153..202
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 206..260
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 371..520
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 153..202
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 206..260
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT COILED 313..368
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 543 AA; 61574 MW; 063A1C3D9A2E966F CRC64;
MSLINCENSC GSSQSESDCC AAMASSCSTA AKDDSVSGVP STSTGNLSSS FMEEIQGYDV
EFDPPLESKY ECPICLMALR EAVQTPCGHR FCKACIIKSI RDAGHKCPVD NEILLENQLF
PDNFAKREIL SLMVKCPNEG CLHKMELRHL EDHQVLCEFA LVNCSQCQRP FQKCQLNIHI
LTDCPRRQVS CVNCAVSMPF EEKEIHDQNC PLANVICEYC HTMLIREQMP THYDLDCPTA
PIPCTFSTFG CHEKMQRNHL ARHLQENTQS HMRMLAQAVH SLNLALTPVP PRDLLPYDAA
SLPRVSSGCH PEVQNFQETI QQLEGRLVRQ DHQIRELTAK METQCMYVNE LKGTIRTLED
KVAEIEAQQC NGIYIWKIGN FGMHLKSQEE EKPVVIHSPG FYTGKPGYKL CMRLHLQLPT
AQRCANYISL FVHTMQGEYD SHLPWPFQGT IRLTILDQSE APVRQNHEEI MDAKPELLAF
QRPTIPRNPK GFGYVTFMHL EALRQRTFIK DDTLLVRCEV STRFDMGGLR KEGFQPRSTD
AGV
//
