ID G5B1C0_HETGA Unreviewed; 214 AA.
AC G5B1C0;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=N(6)-adenine-specific DNA methyltransferase 1 {ECO:0000313|EMBL:EHB03081.1};
GN ORFNames=GW7_13209 {ECO:0000313|EMBL:EHB03081.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03081.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03081.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the eukaryotic/archaeal PrmC-related family.
CC {ECO:0000256|ARBA:ARBA00006149}.
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DR EMBL; JH167925; EHB03081.1; -; Genomic_DNA.
DR RefSeq; XP_004842299.1; XM_004842242.1.
DR AlphaFoldDB; G5B1C0; -.
DR STRING; 10181.G5B1C0; -.
DR Ensembl; ENSHGLT00000075802; ENSHGLP00000029353; ENSHGLG00000036479.
DR GeneID; 101701084; -.
DR KEGG; hgl:101701084; -.
DR CTD; 29104; -.
DR eggNOG; KOG3191; Eukaryota.
DR InParanoid; G5B1C0; -.
DR OMA; EWDDWME; -.
DR OrthoDB; 124743at2759; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR Bgee; ENSHGLG00000016904; Expressed in heart and 10 other cell types or tissues.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004557; PrmC-related.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR NCBIfam; TIGR00537; hemK_rel_arch; 1.
DR PANTHER; PTHR45875; METHYLTRANSFERASE N6AMT1; 1.
DR PANTHER; PTHR45875:SF1; METHYLTRANSFERASE N6AMT1; 1.
DR Pfam; PF05175; MTS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EHB03081.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EHB03081.1}.
FT DOMAIN 31..126
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 214 AA; 23068 MW; 94398202CBCB26D4 CRC64;
MAARSFPTPL HGHVGRGEFS DVYEPAEDTF LLLDALEAAA PELAGVEICL EVGSGSGVVS
VFLASMIGPQ ALYMCTDVNP EAAACTLETA HCNRVHIQPV ITDLVKGLLP RLKEKVDLLV
FNPPYVVTPP EEVGSHGIEA AWAGGRNGRE VMDRFFPLAS DLLSPRGLFY LVTIKENNPE
EILKTLKTKG LHGTTALSRQ AGQEILSVLK FTKC
//
