ID G5B3D3_HETGA Unreviewed; 583 AA.
AC G5B3D3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=hyaluronan synthase {ECO:0000256|ARBA:ARBA00012207};
DE EC=2.4.1.212 {ECO:0000256|ARBA:ARBA00012207};
GN ORFNames=GW7_06235 {ECO:0000313|EMBL:EHB03794.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03794.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03794.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004698}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NodC/HAS family.
CC {ECO:0000256|ARBA:ARBA00006782}.
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DR EMBL; JH168170; EHB03794.1; -; Genomic_DNA.
DR STRING; 10181.G5B3D3; -.
DR eggNOG; KOG2571; Eukaryota.
DR InParanoid; G5B3D3; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:UniProt.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22913; HYALURONAN SYNTHASE; 1.
DR PANTHER; PTHR22913:SF4; HYALURONAN SYNTHASE 1; 1.
DR Pfam; PF13641; Glyco_tranf_2_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 69..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 489..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 8..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 65699 MW; 642FDCD139CB35E1 CRC64;
MTGLQLWATD SRAPEQRPSP QDDPGVWPRV PAPTCVRCDF VGVLRVRLRR DLPKPARTAR
RCSGLARRLL TVAFALLILC LITWAYAAGV PLASDRHGLL AFGLYGAFLS AHLVAQSLFA
YLEHRRVAAA ARRAARRENR RGLPDAGSAR TVALTISAYQ EDPAYLRQCL ASARALLYPR
ARLRVLMVVD GNGAEDLYMV DMFREVFADE DPATYVWDGN YHQPWEPAAA GAVGAGAYRE
RWGGKREVMY TAFKALGDSV DYVQVCDSDT RLDPMALLEL VRVLDEDPQV GAVGGDVRIL
NPLDSWVSFL SSLRYWVAFN VERACQSYFH CVSCISGPLG LYRNNLLQQF LEAWYNQKFL
GTHCTFGDDR HLTNRMLSMG YATKYTSRSR CYSETPSSFL RWLSQQTRWS KSYFREWLYN
ALWWHRHHAW MTYEAVVSGL FPFFVAATVL RLFYAGRPWA LLWVLLCVQG VALAKAAFAA
WLRGCGRMVL LSLYAPLYMC GLLPAKFLAL VTMNQSGXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXRAGGYR VQV
//
