ID G5B3Y4_HETGA Unreviewed; 947 AA.
AC G5B3Y4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=NLR family CARD domain-containing protein 4 {ECO:0000256|ARBA:ARBA00015338};
DE AltName: Full=Ice protease-activating factor {ECO:0000256|ARBA:ARBA00030378};
GN ORFNames=GW7_02624 {ECO:0000313|EMBL:EHB03995.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB03995.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB03995.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
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DR EMBL; JH168371; EHB03995.1; -; Genomic_DNA.
DR AlphaFoldDB; G5B3Y4; -.
DR STRING; 10181.G5B3Y4; -.
DR eggNOG; ENOG502QWRJ; Eukaryota.
DR InParanoid; G5B3Y4; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.1900.50; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR042220; NLRC4.
DR InterPro; IPR040535; NLRC4_HD.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47688; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR47688:SF1; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17889; NLRC4_HD; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..74
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 149..238
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 947 AA; 107100 MW; CE43A736254D4931 CRC64;
MDMTVIKQIV DDLFVWNVLN CEEIGVICRE KVEQDAARGI IHMILKKGSE SCDLFLKSLE
KWNYALFQDL RGKSLFQQIP EGDLDDLAQD LKILYQTPSF LNFYPLGEDF DIIFNLKSIF
TEPVLWRKDH HHRRVEQLTL NGLLETLQNP CVIEGESGKG KTTLLQRIAM LWASGKCTTL
TKFKFVFFLR LSRAQGGLFE TLCDQLLNVP DTIRKWTFMA MLLKLRQGVL FLLDGYNEFK
PQNCPEIEAL IKENHHFKNM VIVTTTTECL SHIRQFGAQI VEVGDMTEHS AQVLIREVLI
KELAEGLLLQ IQKSKSLSNL MKTPLFVIIT CIIQMGEDEF HAHTQTTLFR TFYDLLIQKN
KHKHRGATGA DFSQSLDHCG DLALEGVFSH RFDFELEDVS SENEDVLVTT GLLCKYTAQR
FKPKYKFFHK SFQEYVAGRR LSSFLMSPEA KEVARGDTYL QRMVSISDIT SLYSNLLLYT
CGSSAAATRA VVRHLAGVYQ HGSLLGLSRT KSPLWRQGSI QSVNNTTDQE ILKAININSF
AECGIHLFHE SISKSTLSQE FETFFRGKSL YINSENIPDY LFDFFEHLPN CASALNVVKL
DFYGEALASQ NKATTGEFPE TYIPSRAVSL FFNWKQEFQT LEVILRDFSK LNKKDIKYLG
KIFSSATSLR LYIKRCAGVA GILSSVLGTC KNIHSLLVDT SPLTLEDERH ITSVTHLTAL
SIHNLQTQRL PGGLTDGLGN LKNLMKLILD NIKMNEEDAI ELANGLTNLK KLCLFRLAHL
SDVGEGMDYI VKSLSGEPCD LQEIQLVSCC LTANSVNTLA QNLHNLVKLS ILDLSENYLK
KDGNEALREL SAFFEKNPLK NFQQLDLAEN CVSSDGWLAF MGVLENLQQL VFFDFSAKGI
SPDAALVRKL GHVLSKLTFL QEARLIGWQF DDDDISVIKG AFKLVTA
//
