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Database: UniProt
Entry: G5B549_HETGA
LinkDB: G5B549_HETGA
Original site: G5B549_HETGA 
ID   G5B549_HETGA            Unreviewed;       834 AA.
AC   G5B549;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   27-SEP-2017, entry version 17.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A4 {ECO:0000313|EMBL:JAO01791.1};
GN   ORFNames=GW7_11825 {ECO:0000313|EMBL:EHB04410.1};
OS   Heterocephalus glaber (Naked mole rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Heterocephalus.
OX   NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB04410.1, ECO:0000313|Proteomes:UP000006813};
RN   [1] {ECO:0000313|EMBL:EHB04410.1, ECO:0000313|Proteomes:UP000006813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21993625; DOI=10.1038/nature10533;
RA   Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA   Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA   Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA   Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L.,
RA   Bronson R.T., Buffenstein R., Wang B., Han C., Li Q., Chen L.,
RA   Zhao W., Sunyaev S.R., Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT   "Genome sequencing reveals insights into physiology and longevity of
RT   the naked mole rat.";
RL   Nature 479:223-227(2011).
RN   [2] {ECO:0000313|EMBL:JAO01791.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Kidney {ECO:0000313|EMBL:JAO01791.1};
RA   Bens M., Sahm A., Jahn N., Morhart M., Holtze S., Hildebrandt T.B.,
RA   Platzer M., Szafranski K.;
RT   "FRAMA: From RNA-seq data to annotated mRNA assemblies.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; JH168530; EHB04410.1; -; Genomic_DNA.
DR   EMBL; GEBF01001842; JAO01791.1; -; Transcribed_RNA.
DR   RefSeq; XP_004851305.1; XM_004851248.2.
DR   RefSeq; XP_004851306.1; XM_004851249.2.
DR   GeneID; 101719254; -.
DR   KEGG; hgl:101719254; -.
DR   CTD; 50617; -.
DR   InParanoid; G5B549; -.
DR   KO; K02154; -.
DR   Proteomes; UP000006813; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:Ensembl.
DR   GO; GO:0007588; P:excretion; IEA:Ensembl.
DR   GO; GO:0001503; P:ossification; IEA:Ensembl.
DR   GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006813};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    398    427       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    447    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    596       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    661       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    765    790       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       93    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   834 AA;  95331 MW;  E990EAD749AF5A45 CRC64;
     MVSVFRSEEM CLSQLFLQVE ASYCCVAELG ELGLVQFKDL NASVNSFQRR FVNEVRRCES
     LERILRFLED EMQNEITVQL PEKYPQTPLP RDMIALETTL EKLEGELQEA NQNHQALKKS
     FLELTELKYL LKKTQDFFET EAGLAEDFFI EDTSGLLELR AVPAFMAGKL GFMAGVINRE
     RMASFERLLW RVCRGNIYLK FGEMDTPLED PVTKEEIKKN IFIIFYQGEQ LRQKVKKICD
     GFRATVYPCP EPAAERREML ASVNVRLEDL ATVITQTESH RQGLLQEAAA NWHSWVTKVQ
     KMKAIYHILN MCNIDVTQQC VIAEIWFPVA DTARIKKALE QGMELSGSSM APIMTEVQSK
     TAPPTFNRTN KFTAGFQNMV DAYGVGNYRE MNPTPYTIIT FPFLFAVMFG DCGHGAVMLL
     GALWMILNEE QFLLQKSSNE IWNTFFNGRY LIMLMGIFSI YTGLIYNDCF SKSFNIFGSS
     WSVQPMFRNG TWNAEVMETT PFLQLDPALP GVYSGNPYPF GIDPIWNLAS NKLTFLNSYK
     MKMSVILGIV QMIFGVVLSL FNYIYFRKTH NIILQFIPEM IFILCLFGYL VFMILFKWCH
     YDARVSRSAP SILIHFINMF LFDYDDPSNV PLYEHQREVQ TFFVVMALVS VPWMLLIKPF
     ILRAKHQKSQ LQAFTVQANS AEAVEGGTSG PSRSAETHGA QDDHKEEFNF GDVFVHQAIH
     TIEYCLGCIS NTASYLRLWA LSLAHAELSE VLWTMVMNIG LRLQGWGGLV GVFIIFAVFA
     VLTVAILLIM EGLSAFLHAL RLHWVEFQNK FYVGAGYKFA PFSFKDILEG AAEE
//
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