ID G5B9E2_HETGA Unreviewed; 2124 AA.
AC G5B9E2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=Coagulation factor VIII {ECO:0000313|EMBL:EHB05903.1};
GN ORFNames=GW7_15180 {ECO:0000313|EMBL:EHB05903.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB05903.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB05903.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC {ECO:0000256|ARBA:ARBA00010609}.
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DR EMBL; JH169117; EHB05903.1; -; Genomic_DNA.
DR STRING; 10181.G5B9E2; -.
DR eggNOG; ENOG502QSFZ; Eukaryota.
DR InParanoid; G5B9E2; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR CDD; cd04227; CuRO_3_FVIII_like; 1.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 7.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR011707; Cu-oxidase-like_N.
DR InterPro; IPR011706; Cu-oxidase_C.
DR InterPro; IPR033138; Cu_oxidase_CS.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR024715; Factor_5/8-like.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR46806:SF7; COAGULATION FACTOR VIII; 1.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07731; Cu-oxidase_2; 1.
DR Pfam; PF07732; Cu-oxidase_3; 2.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR PIRSF; PIRSF000354; Factors_V_VIII; 3.
DR SUPFAM; SSF49503; Cupredoxins; 7.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS00079; MULTICOPPER_OXIDASE1; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR000354-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2124
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003474230"
FT DOMAIN 2011..2124
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT REGION 802..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 214..240
FT /evidence="ECO:0000256|PIRSR:PIRSR000354-1"
FT DISULFID 309..390
FT /evidence="ECO:0000256|PIRSR:PIRSR000354-1"
FT DISULFID 590..616
FT /evidence="ECO:0000256|PIRSR:PIRSR000354-1"
FT DISULFID 692..773
FT /evidence="ECO:0000256|PIRSR:PIRSR000354-1"
FT DISULFID 1892..1918
FT /evidence="ECO:0000256|PIRSR:PIRSR000354-1"
FT DISULFID 1959..1963
FT /evidence="ECO:0000256|PIRSR:PIRSR000354-1"
SQ SEQUENCE 2124 AA; 240555 MW; 382788FDB98035AC CRC64;
MQIELSICFF LCLLPFSFSA TRRYYLGAME LPWDYLQSDL LSELHVHTSF PPEMPRSFPF
NSSVVYKKTV FVEFTDHLFN MAKPRPPWMG LLGPTIWAEV YDTVVITLKN MASHPVSLHA
VGVSYWKASE GLLGPTIWAE VYDTVVITLK NMASHPVSLH AVGVSYWKAS EGAEYDDQTS
QREKEDDKVF PGESHTYVWQ VSTENGPMTS DPQCLTYSYF SHVDLVKDLN SGLIGALLVC
KEGSLTKERT QNLNQFVLLF AVFDEGKSWH SETKGLRTQA SDSASAGGWP KMHTVNGYVN
RSLPGLIGCH RKSVYWHVIG MGTTPEVHSI FFEGHTFLVR NHRQASLEIS PITFLTAQTL
LMDLGQFLLY CHISSHQHDG MEAYVKVDSC PEEPHLRMKE DEEEEDYDDD DDDLDSEMDV
FRFDDDYSPF IQIRSAAKKH PKTWIHYIAA EEEDWDYAPS VHASDDRSYK SQYLNNGPQQ
IGRKYKKIRF MAYTDETFKT RETIQYESGI LGPLLYGEVG DTLLIIFKNK ASRPYNIYPH
GISDVSPLHS RRLPKGIKHL KDLPILPGKI FKYKWTVTIE DGPTKSDPRC LTRYYSSFLN
PERDLASGLI GPLLICYKES VDQRGNQMMS DKRNVILFSV FDENRSWYLT ENMQRFLPNV
AGVQAQDPEF QASNIKYSIN GYVFDSLQLS ACLHEVAYWY ILSVGAQTDF LSVFFSGYTF
KHKMVYEDTL TLFPFSGETV FMAMENPGLW VLGCHNSDFR SRGMTALLKV SSCGRSTGDY
YEDTYEDIPT YLLSENHIIE PRSFSQNSRH PTTRQKQFKA TTTAENDKEK TDPQFGERTG
MVKVHNVFSS DLSMLLGQSP TPHGLSLSDI PKATYEALPD DYLPGAIDNN EGPSKVVHIR
PELYQSGDTG FTPEPSLQLR VNENLGTTIA VELKKLDLEV SSSPNNLMVS PAILADNLAA
GPEETSSLGS PNMPVSSQLS TSVLDKKPSP LIGAGVHLSL SERNNESKLL EGVLVNIQES
SLGKNILSME SDMSLKEKTA HGPALLTKDN VLFKVNISLI KTNKTSNYST TNQKTHIDRP
TLLIENSTSV WQGTILERDT EFQRVTSLIH DEVPMDKNTT ALRLNHMSNK TTSSKNLEIV
DQKQADLVPS DEENPDVLFF KMLFLPEPAN WNNGTNGKNS LNSGQGPSPK QLLSLGSELS
GEHQNFLTEE NKVVVENEFT KDAGPKELIP NNKSILLTNL ANVKDNDTHN QEKTIQEEIN
QKKELTQENV VLPQVYTVTG TKNFLKKLFL LSTRQNISLD EGTYAPTLPD TKLLNNSTNR
AKIHKPRFSQ RQEEEETNQD SSRNQTKQMV DKYLSTAGMF PNPSQKNITA QRGKRSLKQF
RFPLEETEVE KGLIVDDPST QRSKNLKYLP QIDYKEKEGK AITQSPLSIS PMRNHSIDQI
KSFALPIAKI SAPPFIRPTD LTQISSQDSS SHFLASTCNY SLKAKSPMAQ EDSHFLQVPK
INNLSLAILP LEIIRKQGKV GSLGTSATNS VAYKKLENTV LLKPVLPETF GKVELLPKVP
IRQEDLLLTE TIHESPVHLD HTEEILLQTT TKTIKWSKTN GPGKAPFLKG TTESSEKMNS
KLLGPLVLGN QYATQMPKDK WRSQEKSPKN TVLKKKDSVL SLIPSESNCT IVAISDGQNR
LQGEATGGKQ GGTGKLCPPN PLVLKRHQRE TTSITLQSEQ EDVYYDDAIS GETKRDFEIY
GEDENQGPRS FQKRTRHYFI AAVERLWDYG MSRIPSVLRN RDQSGSAYQF KKVVFQEFTD
GSFTQPLYRG ELNEHLGLLG PYLRAEVEDN IVVTFKNQAS RPYSFYSSLI SYKDDQKQEA
EPRKNFVKPN ETKTYFWEVQ QHMAPTEDEF DCKAWAYFSD VDLEKDMHTG LIGPLLICHR
NTLSPAHGRQ VTVQEFALLF TIFDETKSWY FTENMERNCK EPCSTQVEDP TFKENYRFHA
INGYVMDTLP GLVMAQNQRI RWYLLSMGSN ENIHSIHFSG HVFTVRKKEE YKMAVYNLYP
GQWAPKLARL HYSGLINAWS TKEPFSWIKV DLLTPMIIHG IKTQGARQKF SSLYISQFII
MYSLDGKKWL TYRGNSTGTL MVCK
//