ID G5BA99_HETGA Unreviewed; 1433 AA.
AC G5BA99;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=GW7_19024 {ECO:0000313|EMBL:EHB06210.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB06210.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB06210.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; JH169222; EHB06210.1; -; Genomic_DNA.
DR STRING; 10181.G5BA99; -.
DR eggNOG; KOG0920; Eukaryota.
DR eggNOG; KOG0923; Eukaryota.
DR eggNOG; KOG1902; Eukaryota.
DR InParanoid; G5BA99; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17987; DEXHc_YTHDC2; 1.
DR CDD; cd06007; R3H_DEXH_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034083; R3H_DEXH_helicase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50882; YTH; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EHB06210.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 42..110
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 207..373
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 510..542
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 616..788
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1291..1421
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1169..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1433 AA; 160552 MW; 444A60A6C9461886 CRC64;
MSRPSSVSPR PPAPGGGGDG GVGGGLAACG SGGGRRAKGL KDIRIDEEVK IAVNIALERF
RYGDQREMEF PSSLTSTERA FIHRLSQSLG LVSKSKGKGA NRYLTVKKKD GSETAHAMMT
CNLTHNTTHA VRSLIQRFPV TNKERTELLP KTERGNVFAV EAENREMSKT SGRLSNGIPQ
IPVKRGESEF DSFRQSLPVF EKQEEIVKII KENKVVLIVG ETGSGKTTQI PQFLLDDCCK
NGIPCRIFCT QPRRLAAIAV AERVAAERKE RIGQTIGYQI RLESRVSPKT LLTFCTNGVL
LRTLMAGDST LSTVTHVIVD EVHERDRFSD FLLTKLRDLL QKHPTLKLIL SSAALDVNLF
IRYFGSCPVI YIQGRPFEVK EMFLEDILRS TGYTNKEMLK YKKEKQREEK QQTTLTEWYS
AQENTFKPES QRQRTVPNVT EEYDLLDDGG DAVFSQLSEK DVNCLEPWLI KEMDTCLSDI
WLHKDVDAFA QVFHLILTEN VSVDYRHSET SATALMVAAG RGFASQVEQL ISMGANVHSK
ASNGWMALDW AKHFGQTEVV DLLESYSASL EFGNLDESSL VQTNGNDLSA EDRELLKAYH
HSFDDEKVDL DLIMHLLYNI CHSCDTGAVL IFLPGYDEIV GLRDRILFDD KRFADSAHRY
QVFMLHSNMQ TSDQKKVLKT PPAGVRKIIL STNIAETSIT VNDVVFVIDS GKVKEKSFDA
LNFVTMLKMV WISKASAKQR KGRAGRCRPG VCFRLFSRIR FQNMLEFQTP ELLRMPLQEL
CLHTKLLAPI SCTIADFLMR APEPPPALIV RNAVQMLKVD AMDAWEDLTE LGYHLADLPV
EPHLGKMVLC AVVLKCLDPI LTIACTLAYR DPFVLPTQAS QKRAAMLCRK RFTAGTFSDH
MALLRAFQAW QKARSDGWER AFCEKNFLSQ ATMEIIIGMR TQLLGQLRAS GFVRARGGGD
IRDVNTNSEN WAVVKAALVA GMYPNLVHVD RENVALTGPK EKKVRFHPTS VLSQPQYKKI
PPANGQAAAI QALPTDWLIY DEMTRAYRIA NIRCCSAVTP VTVLVFCGPA RLPSNALQEP
SSFRADGIPN DSSDSEMEDR TTANLVALKL DEWLNFKLEP EAASLLLQLR QKWHSLFLRR
MRAPSKPWSQ VDEATIRAII AVLSTEEQSA GLQQPSGIGQ RPRPMSSEEL PLASSWRANN
SRKSAADCEF SDESTTAERV LMKSPSTALH PPQKYKDRGI LHPKRSTDDR SDQSYLKSTD
ISSYPGPCAS PSPPSSGKGS KSPSPRPNMP VRYFIMKSSN LRNLEISQQK GIWSTTPSNE
RKLNRAFWES SMVYLVFSVQ GSGHFQGFSR MSSEIGREKS QDWGSTGLGG VFKVEWIRKE
SLPFQFAHHL LNPWNDNKKV QISRDGQELE PQVGEQLLQL WERLPLGEKP TTD
//
