ID G5BCA2_HETGA Unreviewed; 715 AA.
AC G5BCA2;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Scinderin {ECO:0000256|ARBA:ARBA00014288};
DE AltName: Full=Adseverin {ECO:0000256|ARBA:ARBA00030694};
GN ORFNames=GW7_16644 {ECO:0000313|EMBL:EHB06913.1};
OS Heterocephalus glaber (Naked mole rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Heterocephalus.
OX NCBI_TaxID=10181 {ECO:0000313|EMBL:EHB06913.1, ECO:0000313|Proteomes:UP000006813};
RN [1] {ECO:0000313|EMBL:EHB06913.1, ECO:0000313|Proteomes:UP000006813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993625; DOI=10.1038/nature10533;
RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L.,
RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X.,
RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A.,
RA Zhu Y., Chen Y., Kryukov G.V., Zhang Q., Peshkin L., Yang L., Bronson R.T.,
RA Buffenstein R., Wang B., Han C., Li Q., Chen L., Zhao W., Sunyaev S.R.,
RA Park T.J., Zhang G., Wang J., Gladyshev V.N.;
RT "Genome sequencing reveals insights into physiology and longevity of the
RT naked mole rat.";
RL Nature 479:223-227(2011).
CC -!- SUBCELLULAR LOCATION: Cell projection, podosome
CC {ECO:0000256|ARBA:ARBA00004188}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH169535; EHB06913.1; -; Genomic_DNA.
DR AlphaFoldDB; G5BCA2; -.
DR STRING; 10181.G5BCA2; -.
DR eggNOG; KOG0443; Eukaryota.
DR InParanoid; G5BCA2; -.
DR OMA; YPKEKET; -.
DR Proteomes; UP000006813; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11289; gelsolin_S2_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11293; gelsolin_S4_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.40.20.10; Severin; 6.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR PANTHER; PTHR11977:SF78; SCINDERIN; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 6.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 5.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Reference proteome {ECO:0000313|Proteomes:UP000006813}.
FT DOMAIN 28..107
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 147..217
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 264..340
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 410..483
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 526..590
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 627..703
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
SQ SEQUENCE 715 AA; 79903 MW; 27CCF7B32D4BB530 CRC64;
MAQELHHPEV ARAGRQAGLQ IWRIEELELV PVPEGAHGDF FVGDAYVVLH TARTSRGFAY
RLHFWLGKEC SQDESTAAAI FTVQMDDYLG GRPVQSRELQ GFESTDFVGY FKGGLKYKAG
GVASGLNHVL TNDLSAQRLL HVKGRRVVRA TEVPLSWDSF NKGDCFIVDL GSEIYQWCGS
SCNKYERLKA SQVAIGIRDN ERKGRSQLIV VEEGSEPLGL IEVLGKKPEL RDGDSDDDAI
ADISNRKMAK LYMVSDASGS MKVTVVAEEN PFTMAMLLSE ECFILDHGAA KQIFVWKGKD
ANPEERKAAM KTAEEFLQQM NYSTNTQIQV LPEGGETPIF KQFFKDWKDK DQSDGFGKVY
VTEKVARIKQ IPFDASKLHS FPEMAAQHNM VDDGSGKVEI WRVESNGRIE IDPNSYGEFY
GGDCYIILYT YPRGQIIYTW QGANATRDEL TMSAFLTVQL DRSLGGQAVQ VRVSQGKEPA
HLLSLFKDKP LIVYKNGTSK KGGQAPAPPV RLFQVRRNLA SVTRIVEVDV DADSLNSNDA
FVLKLPHNAG YTWVGKGASQ EEEKGAEYVA NVLGCSTARI QEGEEPEEFW TSLGGKKEYQ
TSPLLETQAE DHPPRLYGCS NKSGRFTIEE VPGEFTQDDL AEDDVMLLDA WEQIFIWIGK
DANEVEKTES LKSAKMYLET DPSGRDKKTP IVIIKQGHEP PTFTGWFLGW DSSRW
//
